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Study Information
Study Attribute Value
CEBS Accession Number: 002-01243-0001-0000-3
Chemical Name: 2,5-Dithiobiurea
CASRN: 142-46-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 225305_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 10/27/1982    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1033 477 0.462 9.54 25.7 0.000
Test Chemical 2,5-Dithiobiurea 
14.5       
 50 1018 455 0.447 9.10 25.7 -3.207 
48.3       
 50 1017 474 0.466 9.48 25.7 0.934 
145         
 50 1027 617 0.601 12.34 25.7 30.106 
483         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1016 673 0.662 13.46 25.7 43.451
Mitomycin-C 
 0.01      
 5 101 232 2.297 46.40 25.7 397.449
Trend: 4.392        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 11/10/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1008 461 0.457 9.22 25.5 0.000
Test Chemical 2,5-Dithiobiurea 
149.5       
 50 1020 608 0.596 12.16 32.0 30.336 
201         
 50 1014 690 0.680 13.80 32.0 48.789 
249.2       
 50 1020 661 0.648 13.22 32.0 41.697 
300         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1026 648 0.632 12.96 25.5 38.098
Mitomycin-C 
 0.01      
 5 102 195 1.912 39.00 25.5 318.017
Trend: 6.117        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 10/27/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1041 452 0.434 9.04 25.5 0.000
Test Chemical 2,5-Dithiobiurea 
145         
 50 1035 466 0.450 9.32 25.5 3.695 
483         
 50 1028 549 0.534 10.98 25.5 22.996 
1450         
 50 1031 580 0.563 11.60 25.5 29.563
Positive Control Cyclophosphamide 
 0.3       
 50 1023 667 0.652 13.34 25.5 50.163
Cyclophosphamide 
2         
 5 102 137 1.343 27.40 25.5 209.338
Trend: 4.806        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 11/10/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1033 429 0.415 8.58 25.5 0.000
Test Chemical 2,5-Dithiobiurea 
2320         
 50 1016 601 0.592 12.02 32.0 42.437 
2470         
 50 1023 659 0.644 13.18 32.0 55.115 
2900         
 50 1036 592 0.571 11.84 32.0 37.596
Positive Control Cyclophosphamide 
 0.3       
 50 1042 571 0.548 11.42 25.5 31.951
Cyclophosphamide 
2         
 5 104 151 1.452 30.20 25.5 249.612
Trend: 4.409        
Probability: 0.000