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Study Information
Study Attribute Value
CEBS Accession Number: 002-01243-0002-0000-4
Chemical Name: 2,5-Dithiobiurea
CASRN: 142-46-1
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 225305_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 
No Activation  2  Weakly Positive 

Trial #:1   Activation: No Activation    Date: 12/08/1982    Harvest Time: 20.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 2,5-Dithiobiurea 
351         
 100 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0 0 0.000 0.0 
400         
 100 5 0.050 5.0 1 0.010 1.0 2 0.020 2.0 2 0.020 2.0 
450         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0 
500         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.125     
 50 28 0.560 32.0 16 0.320 22.0 12 0.240 20.0 0 0.000 0.0
Trend: 0.883 -0.908 1.816  
Probability: 0.189 0.818 0.035  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 11/23/1982    Harvest Time: 20.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 2,5-Dithiobiurea 
1740         
 100 4 0.040 3.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0 
2030         
 100 6 0.060 2.0 2 0.020 2.0 4 0.040 2.0 0 0.000 0.0 
2320         
 100 13 0.130 6.0 7 0.070 3.0 5 0.050 5.0 1 0.010 1.0 
2470         
 100 9 0.090 4.0 3 0.030 3.0 6 0.060 3.0 0 0.000 0.0 
2900         
 100 5 0.050 5.0 3 0.030 3.0 2 0.020 2.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 50 9 0.180 18.0 7 0.140 14.0 2 0.040 4.0 0 0.000 0.0
Trend: 1.810 1.412 1.074  
Probability: 0.035 0.079 0.141  


Trial #:2   Activation: No Activation    Date: 11/23/1982    Harvest Time: 20.5 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 2,5-Dithiobiurea 
300         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0 
350         
 100 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 
400         
 100 9 0.090 6.0 1 0.010 1.0 7 0.070 5.0 1 0.010 1.0 
500         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.062     
 50 25 0.500 32.0 11 0.220 20.0 14 0.280 24.0 0 0.000 0.0
Trend: 2.537 1.268 2.147  
Probability: 0.006 0.102 0.016