| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01246-0012-0000-8 |
| Chemical Name: | 2,6-Dichloro-p-phenylenediamine |
| CASRN: | 609-20-1 |
| NTP Study Type: | Genetic Toxicology - Rodent Cytogenetics |
| NTP Study ID: | 479181_SCE |
| Study Result: | Positive |
Table Instructions and Notes:
Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.
| Test Type | Start Date | Sample Time (h) | Species | Sex | Strain | Tissue | Protocol | Trend Test P |
|---|---|---|---|---|---|---|---|---|
| SCE | 12/09/87 | 42 | Mouse | Male | B6C3F1 | Bone Marrow | IP/IJ x 1, 42 hour |
| Dose (mg/kg) | n | SCE / Cell (Mean ± SEM) | Pairwise P | ||
|---|---|---|---|---|---|
| Vehicle Control | Corn Oil | 0 | 4 | 7.14 ± 0.138 | |
| Test Chemical | 2,6-Dichloro-p-phenylenediamine | 100 | 4 | 6.23 ± 0.274 | |
200 | 3 | 10.27 ± 0.810 | |||
400 | 4 | 10.84 ± 0.789 | |||
| Positive Control | Dimethylbenzanthracene | 2.5 | 4 | 13.97 ± 0.535 | |
| Test Type | Start Date | Sample Time (h) | Species | Sex | Strain | Tissue | Protocol | Trend Test P |
|---|---|---|---|---|---|---|---|---|
| SCE | 05/10/88 | 23 | Mouse | Male | B6C3F1 | Bone Marrow | IP/IJ x 1, 23 hour |
| Dose (mg/kg) | n | SCE / Cell (Mean ± SEM) | Pairwise P | ||
|---|---|---|---|---|---|
| Vehicle Control | Corn Oil | 0 | 4 | 4.99 ± 0.394 | |
| Test Chemical | 2,6-Dichloro-p-phenylenediamine | 50 | 4 | 4.93 ± 0.435 | |
100 | 4 | 4.84 ± 0.341 | |||
200 | 4 | 6.97 ± 1.149 | |||
| Positive Control | Dimethylbenzanthracene | 2.5 | 4 | 7.03 ± 0.335 | |
Footnotes: IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed
n: Number of animals analyzed