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Study Information
Study Attribute Value
CEBS Accession Number: 002-01246-0013-0000-9
Chemical Name: 2,6-Dichloro-p-phenylenediamine
CASRN: 609-20-1
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 479181_CA
Study Result: Positive

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 05/04/88 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.1159
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 17.25 ± 2.75 0.0000
Test Chemical 2,6-Dichloro-p-phenylenediamine 
100         
 8 3.00 ± 0.85 0.0035
  
200         
 7 2.00 ± 0.87 0.0299
  
400         
 8 2.25 ± 0.88 0.0168
Vehicle Control No Stressor 
 0         
 8 0.50 ± 0.33 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 07/13/88 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.2311
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
50         
 8 30.00 ± 2.83 0.0000
Test Chemical 2,6-Dichloro-p-phenylenediamine 
100         
 8 2.25 ± 0.59 0.0405
  
200         
 8 1.75 ± 0.45 0.1015
  
400         
 8 1.75 ± 0.70 0.1015
Vehicle Control No Stressor 
 0         
 8 0.75 ± 0.75 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 11/17/88 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.0047
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 18.50 ± 1.99 0.0000
Test Chemical 2,6-Dichloro-p-phenylenediamine 
50         
 7 1.71 ± 0.29 0.1131
  
100         
 8 5.00 ± 2.00 0.0002
  
150         
 8 2.75 ± 0.75 0.0155
Vehicle Control No Stressor 
 0         
 8 0.75 ± 0.37 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed