| Study Attribute | Value |
|---|---|
| CEBS Accession Number: | 002-01250-0004-0000-4 |
| Chemical Name: | 2,6-Diisocyanatotoluene |
| CASRN: | 91-08-7 |
| NTP Study Type: | Genetic Toxicology - Mammalian Cell Mutagenicity |
| NTP Study ID: | 429581 |
| Study Result: | Positive |
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.
| Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
|---|---|---|---|---|---|---|---|
| Vehicle Control | Dimethyl Sulfoxide | 0 | 73 | 115 | 61 | 28 | 29 |
| 65 | 81 | 42 | 22 | ||||
| 67 | 117 | 48 | 24 | ||||
| 53 | 86 | 69 | 43 | ||||
| Test Chemical | 2,6-Diisocyanatotoluene | 15.5625 | 76 | 96 | 74 | 33 | 27 |
| 66 | 79 | 43 | 22 | ||||
31.125 | 56 | 67 | 52 | 31 | 35 | ||
| 61 | 67 | 71 | 39 | ||||
62.5 | 69 | 61 | 86 | 41 | 50* | ||
| 71 | 50 | 127 | 59 | ||||
125 | 55 | 24 | 127 | 77 | 77* | ||
| 53 | 19 | 123 | 78 | ||||
250 | 34 | 5 | 227 | 224 | 177* | ||
| 61 | 10 | 238 | 130 | ||||
500 | |||||||
| Positive Control | Methyl Methane Sulfonate | 15 | 27 | 18 | 120 | 150 | 146* |
| 20 | 16 | 85 | 142 | ||||
| Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
|---|---|---|---|---|---|---|---|
| Vehicle Control | Dimethyl Sulfoxide | 0 | 73 | 104 | 83 | 38 | 32 |
| 63 | 103 | 61 | 33 | ||||
| 77 | 86 | 65 | 28 | ||||
| 75 | 107 | 63 | 28 | ||||
| Test Chemical | 2,6-Diisocyanatotoluene | 25 | 80 | 66 | 118 | 49 | 46 |
| 77 | 57 | 97 | 42 | ||||
50 | 69 | 42 | 131 | 63 | 60* | ||
| 66 | 47 | 113 | 57 | ||||
100 | 60 | 12 | 237 | 131 | 112* | ||
| 61 | 9 | 170 | 93 | ||||
150 | |||||||
| Positive Control | Methyl Methane Sulfonate | 15 | 32 | 18 | 154 | 162 | 166* |
| 32 | 23 | 164 | 171 | ||||
| Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
|---|---|---|---|---|---|---|---|
| Vehicle Control | Dimethyl Sulfoxide | 0 | 74 | 99 | 74 | 33 | 38 |
| 69 | 84 | 92 | 44 | ||||
| 71 | 113 | 71 | 33 | ||||
| 74 | 104 | 88 | 40 | ||||
| Test Chemical | 2,6-Diisocyanatotoluene | 25 | 76 | 74 | 119 | 53 | 42 |
| 73 | 92 | 70 | 32 | ||||
50 | 73 | 44 | 138 | 63 | 54 | ||
| 68 | 50 | 90 | 44 | ||||
100 | 75 | 52 | 142 | 63 | 75* | ||
| 66 | 37 | 171 | 87 | ||||
150 | 56 | 28 | 154 | 91 | 90* | ||
| 59 | 27 | 157 | 89 | ||||
200 | 57 | 11 | 142 | 84 | 96* | ||
| 51 | 15 | 163 | 107 | ||||
250 | |||||||
| Positive Control | 3-Methylcholanthrene | 2.5 | 54 | 30 | 388 | 240 | 284* |
| 35 | 20 | 344 | 328 | ||||
| Conc. ug/mL | Cloning Efficiency | Relative Total Growth | Mutant Colonies | Mutant Frequency | Avg Mutant Frequency | ||
|---|---|---|---|---|---|---|---|
| Vehicle Control | Dimethyl Sulfoxide | 0 | 75 | 101 | 111 | 50 | 56 |
| 49r | 85 | 124 | 84 | ||||
| 57 | 96 | 91 | 53 | ||||
| 69 | 103 | 137 | 66 | ||||
| Test Chemical | 2,6-Diisocyanatotoluene | 10 | 57 | 99 | 106 | 62 | 66 |
| 40 | 50 | 83 | 69 | ||||
25 | 33 | 43 | 116 | 118 | 95* | ||
| 53 | 66 | 114 | 72 | ||||
50 | 38 | 30 | 140 | 123 | 132* | ||
| 40 | 34 | 169 | 141 | ||||
100 | 29 | 8 | 222 | 251 | 229* | ||
| 34 | 9 | 213 | 207 | ||||
150 | 34 | 6 | 258 | 250 | 227* | ||
| 36 | 10 | 219 | 203 | ||||
200 | |||||||
| Positive Control | 3-Methylcholanthrene | 2.5 | 39 | 29 | 674 | 571 | 521* |
| 41 | 30 | 583 | 470 | ||||
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination