Government Funding Lapse

Because of a lapse in government funding, the information on this website may not be up to date, transactions submitted via the website may not be processed, and the agency may not be able to respond to inquiries until appropriations are enacted. The NIH Clinical Center (the research hospital of NIH) is open. For more details about its operating status, please visit  cc.nih.gov. Updates regarding government operating status and resumption of normal operations can be found at opm.gov.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Study Information
Study Attribute Value
CEBS Accession Number: 002-01254-0016-0000-1
Chemical Name: 2,6-Toluenediamine dihydrochloride (2,6-diaminotoluene dihydrochloride)
CASRN: 15481-70-6
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 051468_SCE
Study Result: Negative


Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.


Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 04/15/86 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Phosphate Buffered Saline 
 0         
 4 4.49 ± 0.199
Test Chemical 2,6-Toluenediamine dihydrochloride (2,6-diaminotoluene dihydrochloride) 
45         
 4 5.66 ± 0.414
  
90         
 4 4.94 ± 0.697
  
180         
 4 6.14 ± 0.489
Positive Control Mitomycin-C 
 0.5       
 4 8.95 ± 0.271


Summary of Sister Chromatid Exchange Data (Trial 2)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 01/06/87 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Phosphate Buffered Saline 
 0         
 4 4.32 ± 0.331
Test Chemical 2,6-Toluenediamine dihydrochloride (2,6-diaminotoluene dihydrochloride) 
135         
 4 4.30 ± 0.562
  
180         
 4 5.37 ± 0.431
  
225         
 4 4.15 ± 0.082
Positive Control Mitomycin-C 
 0.5       
 4 7.78 ± 0.638


Summary of Sister Chromatid Exchange Data (Trial 3)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 03/29/88 42 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  42 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Phosphate Buffered Saline 
 0         
 4 5.54 ± 0.478
Test Chemical 2,6-Toluenediamine dihydrochloride (2,6-diaminotoluene dihydrochloride) 
2.5       
 4 5.13 ± 0.415
  
5         
 4 5.17 ± 0.406
  
10         
 4 5.97 ± 0.662
Positive Control Mitomycin-C 
 0.5       
 4 10.32 ± 0.726


Summary of Sister Chromatid Exchange Data (Trial 4)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 06/01/88 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Phosphate Buffered Saline 
 0         
 4 5.74 ± 0.197
Test Chemical 2,6-Toluenediamine dihydrochloride (2,6-diaminotoluene dihydrochloride) 
180         
 4 7.02 ± 0.425
  
270         
 2 6.94 ± 0.811
Positive Control Mitomycin-C 
 0.5       
 4 10.54 ± 1.502


Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed