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Study Information
Study Attribute Value
CEBS Accession Number: 002-01254-0017-0000-2
Chemical Name: 2,6-Toluenediamine dihydrochloride (2,6-diaminotoluene dihydrochloride)
CASRN: 15481-70-6
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 051468_CA
Study Result: Negative

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 04/17/86 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.1924
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Mitomycin-C 
1         
 8 8.00 ± 1.77 0.0000
Test Chemical 2,6-Toluenediamine dihydrochloride (2,6-diaminotoluene dihydrochloride) 
75         
 8 1.50 ± 0.82 0.3807
  
150         
 8 1.75 ± 0.59 0.2804
  
300         
 8 2.00 ± 0.93 0.2008
Vehicle Control No Stressor 
 0         
 8 1.25 ± 0.37 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 09/14/88 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.0750
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Mitomycin-C 
1         
 8 13.25 ± 1.69 0.0000
Test Chemical 2,6-Toluenediamine dihydrochloride (2,6-diaminotoluene dihydrochloride) 
17.5       
 7 2.57 ± 0.84 0.0500
  
35         
 8 0.75 ± 0.53 0.6479
  
70         
 8 2.75 ± 1.06 0.0340
Vehicle Control No Stressor 
 0         
 8 1.00 ± 0.53 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed