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Study Information
Study Attribute Value
CEBS Accession Number: 002-01254-0018-0000-3
Chemical Name: 2,6-Toluenediamine dihydrochloride (2,6-diaminotoluene dihydrochloride)
CASRN: 15481-70-6
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 337746_SCE
Study Result: Negative (Nonstandard Protocol)


Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.


Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 07/16/86 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Phosphate Buffered Saline 
 0         
 4 4.93 ± 0.233
Test Chemical 2,6-Toluenediamine dihydrochloride (2,6-diaminotoluene dihydrochloride) 
25         
 4 5.15 ± 0.258
  
50         
 4 5.02 ± 0.342
  
100         
 4 3.75 ± 0.234
Positive Control Mitomycin-C 
 0.5       
 4 10.01 ± 1.745


Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed