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Study Information
Study Attribute Value
CEBS Accession Number: 002-01254-0019-0000-4
Chemical Name: 2,6-Toluenediamine dihydrochloride (2,6-diaminotoluene dihydrochloride)
CASRN: 15481-70-6
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 337746_CA
Study Result: Negative

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 07/14/86 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.1491
Test Group Dose
(mg/kg)
n Percent Cells w/ Aberrations
(Mean ± SEM)
Pairwise P
Positive Control Mitomycin-C
1         
8 8.00 ± 1.65 0.0000
Test Chemical 2,6-Toluenediamine dihydrochloride (2,6-diaminotoluene dihydrochloride)
25         
8 3.00 ± 0.93 0.0217
 
50         
8 2.75 ± 0.92 0.0340
 
100         
8 2.50 ± 0.82 0.0529
Vehicle Control No Stressor
 0         
8 1.00 ± 0.65 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 01/09/90 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.4534
Test Group Dose
(mg/kg)
n Percent Cells w/ Aberrations
(Mean ± SEM)
Pairwise P
Positive Control Mitomycin-C
1         
8 8.25 ± 1.33 0.0000
Test Chemical 2,6-Toluenediamine dihydrochloride (2,6-diaminotoluene dihydrochloride)
25         
8 0.50 ± 0.33 0.9224
 
50         
8 1.50 ± 0.50 0.5000
 
100         
8 1.25 ± 0.53 0.6193
Vehicle Control No Stressor
 0         
8 1.50 ± 0.50 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed