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Study Information
Study Attribute Value
CEBS Accession Number: 002-01255-0002-0000-7
Chemical Name: 2,6-Xylidine
CASRN: 87-62-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 852885_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #:1   Activation: No Activation    Date: 06/17/1982    Harvest Time: 20.3 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 2,6-Xylidine 
900         
 100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0 
1000         
 100 9 0.090 8.0 2 0.020 2.0 7 0.070 7.0 0 0.000 0.0 
1100         
 100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0 
1200         
 16 3 0.188 19.0 0 0.000 0.0 3 0.188 19.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.125     
 50 48 0.960 44.0 27 0.540 40.0 11 0.220 18.0 10 0.200 1.0
Trend: 2.268 -0.343 2.644  
Probability: 0.012 0.634 0.004  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 06/17/1982    Harvest Time: 20.3 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0
Dimethyl Sulfoxide 
0         
 100 6 0.060 3.0 0 0.000 0.0 5 0.050 3.0 1 0.010 1.0
Test Chemical: 2,6-Xylidine 
1200         
 100 38 0.380 19.0 21 0.210 14.0 17 0.170 12.0 0 0.000 0.0 
1300         
 100 39 0.390 20.0 12 0.120 8.0 17 0.170 14.0 10 0.100 1.0 
1400         
 25 35 1.400 88.0 3 0.120 12.0 19 0.760 64.0 13 0.520 4.0
Positive Control: Cyclophosphamide 
10         
 50 26 0.520 28.0 17 0.340 24.0 9 0.180 10.0 0 0.000 0.0
Trend: 7.442 2.207 6.043  
Probability: 0.000 0.014 0.000