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Study Information
Study Attribute Value
CEBS Accession Number: 002-01257-0002-0000-9
Chemical Name: 2,7-Dinitro-9H-fluoren-9-one
CASRN: 31551-45-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 519842_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Negative 

Trial #:1   Activation: No Activation    Date: 01/25/1984    Harvest Time: 20.3 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 3 0.030 2.0 0 0.000 0.0 3 0.030 2.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 8 0.080 7.0 0 0.000 0.0 7 0.070 6.0 1 0.010 1.0
Test Chemical: 2,7-Dinitro-9H-fluoren-9-one 
10         
 100 5 0.050 5.0 2 0.020 2.0 2 0.020 2.0 1 0.010 1.0 
15         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0 
20         
 100 8 0.080 7.0 3 0.030 3.0 5 0.050 4.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.0625    
 25 14 0.560 36.0 4 0.160 16.0 10 0.400 28.0 0 0.000 0.0
Mitomycin-C 
 0.252     
 100 20 0.200 18.0 11 0.110 11.0 9 0.090 9.0 0 0.000 0.0
Trend: -0.540 1.414 -1.160  
Probability: 0.705 0.079 0.877  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 03/06/1984    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 2,7-Dinitro-9H-fluoren-9-one 
10         
 100 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0 1 0.010 1.0 
15         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
20         
 100 3 0.030 3.0 3 0.030 3.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
5         
 100 10 0.100 8.0 3 0.030 3.0 5 0.050 3.0 2 0.020 2.0
Cyclophosphamide 
20         
 50 10 0.200 16.0 4 0.080 6.0 5 0.100 10.0 1 0.020 2.0
Trend: 0.904 1.248 0.000  
Probability: 0.183 0.106 0.000  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 01/29/1984    Harvest Time: 20.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 9 0.090 9.0 6 0.060 6.0 2 0.020 2.0 1 0.010 1.0
Dimethyl Sulfoxide 
0         
 100 10 0.100 7.0 3 0.030 3.0 7 0.070 4.0 0 0.000 0.0
Test Chemical: 2,7-Dinitro-9H-fluoren-9-one 
10         
 100 8 0.080 6.0 2 0.020 2.0 5 0.050 4.0 1 0.010 1.0 
15         
 100 5 0.050 5.0 2 0.020 2.0 2 0.020 2.0 1 0.010 1.0 
20         
 100 12 0.120 8.0 3 0.030 3.0 7 0.070 5.0 2 0.020 2.0
Positive Control: Cyclophosphamide 
5         
 100 13 0.130 13.0 5 0.050 5.0 8 0.080 8.0 0 0.000 0.0
Cyclophosphamide 
20         
 25 11 0.440 36.0 4 0.160 16.0 7 0.280 24.0 0 0.000 0.0
Trend: 0.133 -0.024 0.047  
Probability: 0.447 0.510 0.481