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Study Information
Study Attribute Value
CEBS Accession Number: 002-01265-0006-0000-2
Chemical Name: 2-Acetylaminofluorene
CASRN: 53-96-3
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 172752_CA
Study Result: Positive

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 07/28/83 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.0134
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Test Chemical 2-Acetylaminofluorene 
250         
 8 5.50 ± 1.24 0.0002
  
500         
 8 3.00 ± 1.00 0.0217
  
1000         
 8 5.00 ± 1.20 0.0005
Vehicle Control No Stressor 
 0         
 8 1.00 ± 0.53 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 02/14/85 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.0157
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Test Chemical 2-Acetylaminofluorene 
446         
 5 6.02 ± 0.00 0.0157
Vehicle Control No Stressor 
 0         
 5 1.40 ± 0.51 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 07/29/87 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 25.00 ± 3.84 0.0000
Test Chemical 2-Acetylaminofluorene 
200         
 8 1.50 ± 0.50 0.9574
  
400         
 8 1.25 ± 0.53 0.9772
  
800         
 8 53.75 ± 16.70 0.0000
Vehicle Control No Stressor 
 0         
 7 3.43 ± 1.04 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed