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Study Information
Study Attribute Value
CEBS Accession Number: 002-01265-0007-0000-3
Chemical Name: 2-Acetylaminofluorene
CASRN: 53-96-3
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 242744_CA
Study Result: Positive (Nonstandard Protocol)

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 06/20/83 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.9511
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Test Chemical 2-Acetylaminofluorene 
125         
 4 3.50 ± 0.29 0.8535
  
250         
 4 2.75 ± 0.85 0.9504
  
500         
 4 2.75 ± 1.11 0.9504
Vehicle Control No Stressor 
 0         
 4 5.00 ± 0.91 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 05/04/88 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.0000
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
100         
 8 28.25 ± 4.54 0.0000
Test Chemical 2-Acetylaminofluorene 
125         
 8 1.50 ± 0.73 0.2622
  
250         
 8 3.50 ± 0.91 0.0086
  
500         
 8 6.25 ± 2.09 0.0000
Vehicle Control No Stressor 
 0         
 8 1.00 ± 0.38 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed