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Study Information
Study Attribute Value
CEBS Accession Number: 002-01277-0001-0000-0
Chemical Name: 2-Amino-4-nitrophenol
CASRN: 99-57-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 483411_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Test Failure 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 01/25/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1029 600 0.583 12.00 25.5 0.000
Test Chemical 2-Amino-4-nitrophenol 
5         
 50 1018 720 0.707 14.40 25.5 21.297 
16.7       
 50 1012 1048 1.036 20.96 34.3 77.601 
50         
 50 1013 1074 1.060 21.48 34.3 81.827
Positive Control Mitomycin-C 
 0.001     
 50 1036 644 0.622 12.88 25.5 6.608
Mitomycin-C 
 0.01      
 5 103 259 2.515 51.80 25.5 331.248
Trend: 13.743        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 01/25/1983    Trial Call: Test Failure   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1018 548 0.538 10.96 25.5 0.000
Test Chemical 2-Amino-4-nitrophenol 
1670         
 50 1021 569 0.557 11.38 25.5 3.527 
5000         
 0 0 0 0.000 0.00 0.0 N/A
Trend: 0.579        
Probability: 0.281        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 03/01/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1036 424 0.409 8.48 25.5 0.000
Test Chemical 2-Amino-4-nitrophenol 
1740         
 50 1031 616 0.597 12.32 25.5 45.988 
2180         
 50 1015 744 0.733 14.88 34.0 79.102 
2670         
 50 1007 936 0.929 18.72 34.0 127.112
Positive Control Cyclophosphamide 
 0.3       
 50 1041 664 0.638 13.28 25.5 55.852
Cyclophosphamide 
2         
 5 104 146 1.404 29.20 25.5 243.015
Trend: 14.840        
Probability: 0.000