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Study Information
Study Attribute Value
CEBS Accession Number: 002-01277-0002-0000-1
Chemical Name: 2-Amino-4-nitrophenol
CASRN: 99-57-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 483411_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #:1   Activation: No Activation    Date: 03/10/1983    Harvest Time: 20.8 hour(s)   Trial Call: Weakly Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 2-Amino-4-nitrophenol 
150         
 100 12 0.120 3.0 0 0.000 0.0 1 0.010 1.0 11 0.110 2.0 
199         
 100 7 0.070 6.0 4 0.040 4.0 2 0.020 2.0 1 0.010 1.0 
249         
 100 12 0.120 11.0 6 0.060 6.0 3 0.030 3.0 3 0.030 3.0 
300         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.0625    
 50 18 0.360 26.0 16 0.320 24.0 2 0.040 4.0 0 0.000 0.0
Trend: 2.934 2.134 1.838  
Probability: 0.002 0.016 0.033  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 03/10/1983    Harvest Time: 20.8 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0
Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0 1 0.010 1.0
Test Chemical: 2-Amino-4-nitrophenol 
2460         
 100 14 0.140 5.0 1 0.010 1.0 1 0.010 1.0 12 0.120 3.0 
2760         
 100 103 1.030 28.0 35 0.350 19.0 15 0.150 11.0 53 0.530 8.0 
2990         
 50 74 1.480 34.0 16 0.320 18.0 6 0.120 10.0 52 1.040 14.0 
3520         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
10         
 50 10 0.200 18.0 6 0.120 12.0 4 0.080 8.0 0 0.000 0.0
Trend: 6.835 5.479 3.964  
Probability: 0.000 0.000 0.000