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Study Information
Study Attribute Value
CEBS Accession Number: 002-01283-0001-0000-7
Chemical Name: 2-Amino-5-nitrophenol
CASRN: 121-88-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 854073_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 02/02/1983    Trial Call: Positive   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide
0         
50 1026 416 0.405 8.32 25.5 0.000
Test Chemical 2-Amino-5-nitrophenol
4         
50 1032 477 0.462 9.54 25.5 13.997
13.3       
50 1029 582 0.566 11.64 25.5 39.496
40         
50 1034 751 0.726 15.02 25.5 79.132
133.3       
0 0 0 0.000 0.00 31.0 N/A
Positive Control Mitomycin-C
 0.001     
50 1020 711 0.697 14.22 25.5 71.919
Mitomycin-C
 0.01      
5 102 198 1.941 39.60 25.5 378.761
Trend: 10.383        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 02/02/1983    Trial Call: Weakly Positive   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide
0         
50 1037 405 0.391 8.10 25.5 0.000
Test Chemical 2-Amino-5-nitrophenol
133.3       
50 1029 385 0.374 7.70 25.5 -4.199
400         
50 1033 411 0.398 8.22 25.5 1.874
1300         
50 1020 606 0.594 12.12 31.0 52.123
4000         
0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide
 0.3       
50 1041 610 0.586 12.20 25.5 50.039
Cyclophosphamide
2         
5 105 203 1.933 40.60 25.5 395.029
Trend: 6.897        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 02/22/1983    Trial Call: Positive   
  Dose
µg/mL
Number
Cells
Examined
Number
Chromosomes
Examined
Total
Number
SCEs
SCE /
Chromosome
SCE /
Cell
Hours in
BRDU
% Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide
0         
50 1026 428 0.417 8.56 25.5 0.000
Test Chemical 2-Amino-5-nitrophenol
907         
50 1006 715 0.711 14.30 25.5 70.377
1010         
50 1006 656 0.652 13.12 32.8 56.318
1240         
50 1015 848 0.835 16.96 32.8 100.278
1500         
0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide
 0.3       
50 1026 603 0.588 12.06 25.5 40.888
Cyclophosphamide
2         
5 105 159 1.514 31.80 25.5 263.004
Trend: 10.936        
Probability: 0.000