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Study Information
Study Attribute Value
CEBS Accession Number: 002-01283-0001-0000-7
Chemical Name: 2-Amino-5-nitrophenol
CASRN: 121-88-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 854073_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 02/02/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1026 416 0.405 8.32 25.5 0.000
Test Chemical 2-Amino-5-nitrophenol 
4         
 50 1032 477 0.462 9.54 25.5 13.997 
13.3       
 50 1029 582 0.566 11.64 25.5 39.496 
40         
 50 1034 751 0.726 15.02 25.5 79.132 
133.3       
 0 0 0 0.000 0.00 31.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1020 711 0.697 14.22 25.5 71.919
Mitomycin-C 
 0.01      
 5 102 198 1.941 39.60 25.5 378.761
Trend: 10.383        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 02/02/1983    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1037 405 0.391 8.10 25.5 0.000
Test Chemical 2-Amino-5-nitrophenol 
133.3       
 50 1029 385 0.374 7.70 25.5 -4.199 
400         
 50 1033 411 0.398 8.22 25.5 1.874 
1300         
 50 1020 606 0.594 12.12 31.0 52.123 
4000         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.3       
 50 1041 610 0.586 12.20 25.5 50.039
Cyclophosphamide 
2         
 5 105 203 1.933 40.60 25.5 395.029
Trend: 6.897        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 02/22/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1026 428 0.417 8.56 25.5 0.000
Test Chemical 2-Amino-5-nitrophenol 
907         
 50 1006 715 0.711 14.30 25.5 70.377 
1010         
 50 1006 656 0.652 13.12 32.8 56.318 
1240         
 50 1015 848 0.835 16.96 32.8 100.278 
1500         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.3       
 50 1026 603 0.588 12.06 25.5 40.888
Cyclophosphamide 
2         
 5 105 159 1.514 31.80 25.5 263.004
Trend: 10.936        
Probability: 0.000