COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-01283-0002-0000-8
Chemical Name: 2-Amino-5-nitrophenol
CASRN: 121-88-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 854073_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 
No Activation  2  Positive 

Trial #:1   Activation: No Activation    Date: 02/15/1983    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: 2-Amino-5-nitrophenol 
405         
 96 4 0.042 4.2 0 0.000 0.0 3 0.031 3.0 1 0.010 1.0 
450         
 85 5 0.059 4.7 2 0.024 2.4 1 0.012 1.2 2 0.024 2.3 
500         
 71 1 0.014 1.4 1 0.014 1.4 0 0.000 0.0 0 0.000 0.0 
1000         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.5       
 50 31 0.620 38.0 15 0.300 26.0 16 0.320 24.0 0 0.000 0.0
Trend: 0.842 1.430 -0.253  
Probability: 0.200 0.076 0.600  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 03/03/1983    Harvest Time: 20.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 2-Amino-5-nitrophenol 
905         
 100 31 0.310 22.0 4 0.040 4.0 27 0.270 20.0 0 0.000 0.0 
1000         
 100 33 0.330 21.0 7 0.070 5.0 26 0.260 19.0 0 0.000 0.0 
1240         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
10         
 50 49 0.980 50.0 30 0.600 40.0 19 0.380 26.0 0 0.000 0.0
Trend: 4.546 2.148 4.289  
Probability: 0.000 0.016 0.000  


Trial #:2   Activation: No Activation    Date: 03/15/1983    Harvest Time: 20.8 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 5 0.050 2.0 1 0.010 1.0 4 0.040 1.0 0 0.000 0.0
Test Chemical: 2-Amino-5-nitrophenol 
49.5       
 100 12 0.120 11.0 7 0.070 7.0 5 0.050 5.0 0 0.000 0.0 
100.5       
 100 14 0.140 13.0 5 0.050 5.0 6 0.060 6.0 3 0.030 3.0 
149.9       
 100 25 0.250 20.0 5 0.050 5.0 18 0.180 13.0 2 0.020 2.0
Positive Control: Mitomycin-C 
 0.0625    
 50 73 1.460 58.0 41 0.820 48.0 22 0.440 24.0 10 0.200 2.0
Trend: 3.856 1.073 3.296  
Probability: 0.000 0.142 0.000