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Study Information
Study Attribute Value
CEBS Accession Number: 002-01283-0002-0000-8
Chemical Name: 2-Amino-5-nitrophenol
CASRN: 121-88-0
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 854073_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 
No Activation  2  Positive 

Trial #:1   Activation: No Activation    Date: 02/15/1983    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: 2-Amino-5-nitrophenol 
405         
 96 4 0.042 4.2 0 0.000 0.0 3 0.031 3.0 1 0.010 1.0 
450         
 85 5 0.059 4.7 2 0.024 2.4 1 0.012 1.2 2 0.024 2.3 
500         
 71 1 0.014 1.4 1 0.014 1.4 0 0.000 0.0 0 0.000 0.0 
1000         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.5       
 50 31 0.620 38.0 15 0.300 26.0 16 0.320 24.0 0 0.000 0.0
Trend: 0.842 1.430 -0.253  
Probability: 0.200 0.076 0.600  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 03/03/1983    Harvest Time: 20.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 2-Amino-5-nitrophenol 
905         
 100 31 0.310 22.0 4 0.040 4.0 27 0.270 20.0 0 0.000 0.0 
1000         
 100 33 0.330 21.0 7 0.070 5.0 26 0.260 19.0 0 0.000 0.0 
1240         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
10         
 50 49 0.980 50.0 30 0.600 40.0 19 0.380 26.0 0 0.000 0.0
Trend: 4.546 2.148 4.289  
Probability: 0.000 0.016 0.000  


Trial #:2   Activation: No Activation    Date: 03/15/1983    Harvest Time: 20.8 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 5 0.050 2.0 1 0.010 1.0 4 0.040 1.0 0 0.000 0.0
Test Chemical: 2-Amino-5-nitrophenol 
49.5       
 100 12 0.120 11.0 7 0.070 7.0 5 0.050 5.0 0 0.000 0.0 
100.5       
 100 14 0.140 13.0 5 0.050 5.0 6 0.060 6.0 3 0.030 3.0 
149.9       
 100 25 0.250 20.0 5 0.050 5.0 18 0.180 13.0 2 0.020 2.0
Positive Control: Mitomycin-C 
 0.0625    
 50 73 1.460 58.0 41 0.820 48.0 22 0.440 24.0 10 0.200 2.0
Trend: 3.856 1.073 3.296  
Probability: 0.000 0.142 0.000