COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-01284-0001-0000-8
Chemical Name: 2-Amino-5-nitrothiazole
CASRN: 121-66-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 365768_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Weakly Positive 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 03/11/1987    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1044 408 0.391 8.16 26.0 0.000
Test Chemical 2-Amino-5-nitrothiazole 
1.6       
 50 1050 526 0.501 10.52 26.0 28.185 
5         
 50 1049 504 0.480 10.08 26.0 22.941 
16         
 50 1049 582 0.555 11.64 26.0 41.967 
50         
 50 1044 711 0.681 14.22 26.0 74.265 
160         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Mitomycin-C 
 0.0E-4    
 50 1050 577 0.550 11.54 26.0 40.613
Mitomycin-C 
 0.005     
 10 210 285 1.357 28.50 26.0 247.269
Trend: 8.975        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 07/21/1987    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1039 419 0.403 8.38 26.0 0.000
Test Chemical 2-Amino-5-nitrothiazole 
1.6       
 50 1039 395 0.380 7.90 26.0 -5.728 
5         
 50 1033 331 0.320 6.62 26.0 -20.544 
16         
 50 1047 449 0.429 8.98 26.0 6.341 
50         
 50 1026 555 0.541 11.10 26.0 34.137
Positive Control Mitomycin-C 
 0.0E-4    
 50 1048 504 0.481 10.08 26.0 19.253
Mitomycin-C 
 0.005     
 10 210 254 1.210 25.40 26.0 199.927
Trend: 5.100        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 03/11/1987    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 477 0.455 9.54 26.0 0.000
Test Chemical 2-Amino-5-nitrothiazole 
5         
 50 1050 506 0.482 10.12 26.0 5.979 
16         
 50 1050 469 0.447 9.38 26.0 -1.771 
50         
 50 1051 509 0.484 10.18 26.0 6.506 
160         
 50 1050 531 0.506 10.62 26.0 11.215
Positive Control Cyclophosphamide 
 0.15      
 50 1050 629 0.599 12.58 26.0 31.740
Cyclophosphamide 
 0.6       
 10 210 222 1.057 22.20 26.0 132.483
Trend: 1.550        
Probability: 0.061