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Study Information
Study Attribute Value
CEBS Accession Number: 002-01284-0002-0000-9
Chemical Name: 2-Amino-5-nitrothiazole
CASRN: 121-66-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 365768_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Negative 
No Activation  2  Positive 

Trial #:1   Activation: No Activation    Date: 06/16/1987    Harvest Time: 12 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: 2-Amino-5-nitrothiazole 
50         
 200 11 0.055 3.5 1 0.005 0.5 9 0.045 3.5 1 0.005 1.0 
100         
 200 5 0.025 2.5 1 0.005 0.5 4 0.020 2.0 0 0.000 0.0 
160         
 200 12 0.060 5.0 1 0.005 0.5 11 0.055 4.5 0 0.000 0.0 
300         
 100 157 1.570 70.0 5 0.050 5.0 131 1.310 66.0 21 0.210 3.0
Positive Control: Mitomycin-C 
 0.0625    
 200 49 0.245 22.0 22 0.110 10.5 27 0.135 12.5 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 20 0.400 34.0 4 0.080 8.0 16 0.320 28.0 0 0.000 0.0
Trend: 13.330 3.165 12.846  
Probability: 0.000 0.001 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 06/16/1987    Harvest Time: 13 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 2-Amino-5-nitrothiazole 
50         
 200 4 0.020 2.0 0 0.000 0.0 4 0.020 2.0 0 0.000 0.0 
100         
 200 3 0.015 1.5 1 0.005 0.5 2 0.010 1.0 0 0.000 0.0 
300         
 200 3 0.015 1.0 1 0.005 0.5 2 0.010 1.0 0 0.000 0.0 
500         
 112 2 0.018 1.8 0 0.000 0.0 2 0.018 1.8 0 0.000 0.0
Positive Control: Cyclophosphamide 
2.5       
 200 38 0.190 18.0 3 0.015 1.5 35 0.175 16.5 0 0.000 0.0
Cyclophosphamide 
5         
 50 15 0.300 28.0 3 0.060 6.0 12 0.240 24.0 0 0.000 0.0
Trend: 0.858 0.768 0.889  
Probability: 0.196 0.221 0.187  


Trial #:2   Activation: No Activation    Date: 09/23/1987    Harvest Time: 12 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 4 0.020 2.0 0 0.000 0.0 4 0.020 2.0 0 0.000 0.0
Test Chemical: 2-Amino-5-nitrothiazole 
100         
 200 11 0.055 5.5 1 0.005 0.5 10 0.050 5.0 0 0.000 0.0 
160         
 200 15 0.075 7.5 1 0.005 0.5 14 0.070 7.0 0 0.000 0.0 
225         
 200 18 0.090 9.0 1 0.005 0.5 17 0.085 8.5 0 0.000 0.0 
300         
 100 58 0.580 43.0 5 0.050 5.0 53 0.530 39.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.0625    
 200 42 0.210 18.0 9 0.045 4.5 33 0.165 15.0 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 14 0.280 26.0 5 0.100 10.0 9 0.180 16.0 0 0.000 0.0
Trend: 8.308 2.943 7.836  
Probability: 0.000 0.002 0.000