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Study Information
Study Attribute Value
CEBS Accession Number: 002-01289-0001-0000-3
Chemical Name: 2-Aminoanthracene
CASRN: 613-13-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 322797_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Test Failure 
Induced Rat Liver S9  2_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 06/26/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1041 418 0.402 8.36 25.6 0.000
Test Chemical 2-Aminoanthracene 
150         
 50 1045 692 0.662 13.84 25.6 64.917 
500         
 50 1017 642 0.631 12.84 25.6 57.213 
1500         
 50 1035 686 0.663 13.72 25.6 65.066
Trend: 7.067        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 07/17/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 25 520 256 0.492 10.24 31.3 0.000
Test Chemical 2-Aminoanthracene 
1500         
 25 517 367 0.710 14.68 31.3 44.191 
2000         
 25 516 405 0.785 16.20 31.3 59.430 
2500         
 25 519 428 0.825 17.12 31.3 67.510 
3000         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.0015    
 25 512 351 0.686 14.04 25.5 39.252
Mitomycin-C 
 0.01      
 5 104 249 2.394 49.80 25.5 386.328
Trend: 6.496        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 06/26/1984    Trial Call: Test Failure   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1031 414 0.402 8.28 25.6 0.000
Test Chemical 2-Aminoanthracene 
 0.15      
 50 1041 484 0.465 9.68 25.6 15.785 
 0.5       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
2         
 5 104 154 1.481 30.80 25.6 268.762
Trend: 2.191        
Probability: 0.014        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 07/19/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1031 461 0.447 9.22 25.5 0.000
Test Chemical 2-Aminoanthracene 
 0.4       
 50 1012 481 0.475 9.62 25.5 6.297 
 0.45      
 50 1042 510 0.489 10.20 25.5 9.461 
 0.5       
 50 1014 525 0.518 10.50 25.5 15.792
Positive Control Cyclophosphamide 
 0.4       
 50 1041 714 0.686 14.28 25.5 53.393
Cyclophosphamide 
2         
 5 105 170 1.619 34.00 25.5 262.091
Trend: 2.321        
Probability: 0.010