U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Study Information
Study Attribute Value
CEBS Accession Number: 002-01289-0002-0000-4
Chemical Name: 2-Aminoanthracene
CASRN: 613-13-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 322797_CA
Study Result: Equivocal

Study Result: Equivocal
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Test Failure 
Induced Rat Liver S9  3_S9  Negative 

Trial #:1   Activation: No Activation    Date: 09/19/1984    Harvest Time: 12.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: 2-Aminoanthracene 
246.5       
 100 3 0.030 2.0 0 0.000 0.0 3 0.030 2.0 0 0.000 0.0 
1000         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0 
1200         
 100 2 0.020 2.0 0 0.000 0.0 1 0.010 1.0 1 0.010 1.0 
1500         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.15      
 100 17 0.170 16.0 9 0.090 9.0 8 0.080 8.0 0 0.000 0.0
Mitomycin-C 
 0.51      
 25 11 0.440 32.0 5 0.200 16.0 6 0.240 20.0 0 0.000 0.0
Trend: -0.994 -0.649 -1.242  
Probability: 0.840 0.742 0.893  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 10/04/1984    Harvest Time: 12.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 2-Aminoanthracene 
15         
 100 7 0.070 6.0 6 0.060 5.0 1 0.010 1.0 0 0.000 0.0 
20         
 100 8 0.080 8.0 6 0.060 6.0 2 0.020 2.0 0 0.000 0.0 
25         
 100 19 0.190 9.0 3 0.030 3.0 6 0.060 5.0 10 0.100 1.0
Positive Control: Cyclophosphamide 
7.5       
 100 18 0.180 9.0 5 0.050 5.0 3 0.030 3.0 10 0.100 1.0
Cyclophosphamide 
32.5       
 25 12 0.480 28.0 4 0.160 16.0 8 0.320 16.0 0 0.000 0.0
Trend: 2.462 0.879 2.521  
Probability: 0.007 0.190 0.006  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 09/19/1984    Harvest Time: 12.5 hour(s)   Trial Call: Test Failure   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: 2-Aminoanthracene 
2         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
37.5       
 25 15 0.600 48.0 5 0.200 20.0 10 0.400 32.0 0 0.000 0.0
Trend: 0.000 0.000 0.000  
Probability: 0.000 0.000 0.000  


Trial #:3_S9   Activation: Induced Rat Liver S9    Date: 10/24/1984    Harvest Time: 12.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0
Test Chemical: 2-Aminoanthracene 
35.1       
 100 7 0.070 6.0 4 0.040 4.0 2 0.020 2.0 1 0.010 1.0 
40         
 100 9 0.090 7.0 8 0.080 6.0 1 0.010 1.0 0 0.000 0.0 
45         
 100 9 0.090 6.0 3 0.030 3.0 6 0.060 4.0 0 0.000 0.0 
50         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
7.5       
 100 15 0.150 10.0 6 0.060 5.0 9 0.090 7.0 0 0.000 0.0
Cyclophosphamide 
37.5       
 25 21 0.840 52.0 8 0.320 24.0 13 0.520 36.0 0 0.000 0.0
Trend: 0.981 1.395 0.274  
Probability: 0.163 0.081 0.392