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Study Information
Study Attribute Value
CEBS Accession Number: 002-01289-0002-0000-4
Chemical Name: 2-Aminoanthracene
CASRN: 613-13-8
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 322797_CA
Study Result: Equivocal

Study Result: Equivocal
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Test Failure 
Induced Rat Liver S9  3_S9  Negative 

Trial #:1   Activation: No Activation    Date: 09/19/1984    Harvest Time: 12.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: 2-Aminoanthracene 
246.5       
 100 3 0.030 2.0 0 0.000 0.0 3 0.030 2.0 0 0.000 0.0 
1000         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0 
1200         
 100 2 0.020 2.0 0 0.000 0.0 1 0.010 1.0 1 0.010 1.0 
1500         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.15      
 100 17 0.170 16.0 9 0.090 9.0 8 0.080 8.0 0 0.000 0.0
Mitomycin-C 
 0.51      
 25 11 0.440 32.0 5 0.200 16.0 6 0.240 20.0 0 0.000 0.0
Trend: -0.994 -0.649 -1.242  
Probability: 0.840 0.742 0.893  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 10/04/1984    Harvest Time: 12.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 2-Aminoanthracene 
15         
 100 7 0.070 6.0 6 0.060 5.0 1 0.010 1.0 0 0.000 0.0 
20         
 100 8 0.080 8.0 6 0.060 6.0 2 0.020 2.0 0 0.000 0.0 
25         
 100 19 0.190 9.0 3 0.030 3.0 6 0.060 5.0 10 0.100 1.0
Positive Control: Cyclophosphamide 
7.5       
 100 18 0.180 9.0 5 0.050 5.0 3 0.030 3.0 10 0.100 1.0
Cyclophosphamide 
32.5       
 25 12 0.480 28.0 4 0.160 16.0 8 0.320 16.0 0 0.000 0.0
Trend: 2.462 0.879 2.521  
Probability: 0.007 0.190 0.006  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 09/19/1984    Harvest Time: 12.5 hour(s)   Trial Call: Test Failure   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: 2-Aminoanthracene 
2         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
37.5       
 25 15 0.600 48.0 5 0.200 20.0 10 0.400 32.0 0 0.000 0.0
Trend: 0.000 0.000 0.000  
Probability: 0.000 0.000 0.000  


Trial #:3_S9   Activation: Induced Rat Liver S9    Date: 10/24/1984    Harvest Time: 12.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0
Test Chemical: 2-Aminoanthracene 
35.1       
 100 7 0.070 6.0 4 0.040 4.0 2 0.020 2.0 1 0.010 1.0 
40         
 100 9 0.090 7.0 8 0.080 6.0 1 0.010 1.0 0 0.000 0.0 
45         
 100 9 0.090 6.0 3 0.030 3.0 6 0.060 4.0 0 0.000 0.0 
50         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
7.5       
 100 15 0.150 10.0 6 0.060 5.0 9 0.090 7.0 0 0.000 0.0
Cyclophosphamide 
37.5       
 25 21 0.840 52.0 8 0.320 24.0 13 0.520 36.0 0 0.000 0.0
Trend: 0.981 1.395 0.274  
Probability: 0.163 0.081 0.392