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Study Information
Study Attribute Value
CEBS Accession Number: 002-01290-0001-0000-5
Chemical Name: 2-Aminoanthraquinone
CASRN: 117-79-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 230007_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 10/27/1987    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 465 0.443 9.30 26.0 0.000
Test Chemical 2-Aminoanthraquinone 
16         
 50 1032 793 0.768 15.86 26.0 73.512 
50         
 50 1043 805 0.772 16.10 26.0 74.280 
160         
 50 1037 870 0.839 17.40 26.0 89.442 
500         
 50 1037 800 0.771 16.00 26.0 74.200
Positive Control Mitomycin-C 
 0.0E-4    
 50 1043 561 0.538 11.22 26.0 21.455
Mitomycin-C 
 0.005     
 10 210 252 1.200 25.20 26.0 170.968
Trend: 8.811        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 10/27/1987    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 397 0.378 7.94 26.0 0.000
Test Chemical 2-Aminoanthraquinone 
16         
 50 1051 841 0.800 16.82 26.0 111.436 
50         
 50 1047 890 0.850 17.80 26.0 124.610 
160         
 50 1050 1069 1.018 21.38 26.0 169.013 
500         
 50 1046 1182 1.130 23.64 26.0 198.587
Positive Control Cyclophosphamide 
 0.1       
 50 1045 474 0.454 9.48 26.0 19.852
Cyclophosphamide 
 0.6       
 10 209 215 1.029 21.50 26.0 171.817
Trend: 19.279        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 12/15/1987    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1051 437 0.416 8.74 26.0 0.000
Test Chemical 2-Aminoanthraquinone 
100         
 25 525 460 0.876 18.40 26.0 110.727 
160         
 10 210 222 1.057 22.20 26.0 154.246 
300         
 10 210 244 1.162 24.40 26.0 179.442 
500         
 10 210 258 1.229 25.80 26.0 195.476
Positive Control Cyclophosphamide 
 0.1       
 50 1048 528 0.504 10.56 26.0 21.170
Cyclophosphamide 
 0.6       
 10 210 216 1.029 21.60 26.0 147.375
Trend: 16.474        
Probability: 0.000