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Study Information
Study Attribute Value
CEBS Accession Number: 002-01290-0002-0000-6
Chemical Name: 2-Aminoanthraquinone
CASRN: 117-79-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 230007_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 
No Activation  2  Positive 

Trial #:1   Activation: No Activation    Date: 12/10/1987    Harvest Time: 12 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: 2-Aminoanthraquinone 
160         
 50 37 0.740 48.0 14 0.280 26.0 23 0.460 16.0 0 0.000 0.0 
300         
 50 76 1.520 72.0 19 0.380 32.0 57 1.140 60.0 0 0.000 0.0 
500         
 50 53 1.060 54.0 17 0.340 26.0 26 0.520 40.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.0625    
 200 27 0.135 13.0 2 0.010 1.0 25 0.125 12.0 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 15 0.300 24.0 2 0.040 4.0 13 0.260 20.0 0 0.000 0.0
Trend: 11.100 7.073 9.799  
Probability: 0.000 0.000 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 12/10/1987    Harvest Time: 13 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: 2-Aminoanthraquinone 
160         
 200 21 0.105 9.5 6 0.030 2.5 15 0.075 7.5 0 0.000 0.0 
300         
 200 43 0.215 17.5 13 0.065 6.0 30 0.150 13.5 0 0.000 0.0 
500         
 200 43 0.215 18.0 12 0.060 6.0 31 0.155 14.5 0 0.000 0.0
Positive Control: Cyclophosphamide 
2.5       
 200 20 0.100 10.0 0 0.000 0.0 20 0.100 10.0 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 17 0.340 30.0 1 0.020 2.0 16 0.320 30.0 0 0.000 0.0
Trend: 5.906 3.680 5.149  
Probability: 0.000 0.000 0.000  


Trial #:2   Activation: No Activation    Date: 12/21/1987    Harvest Time: 12 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: 2-Aminoanthraquinone 
160         
 200 43 0.215 17.5 16 0.080 7.5 27 0.135 12.0 0 0.000 0.0 
300         
 200 65 0.325 25.0 39 0.195 16.0 26 0.130 11.0 0 0.000 0.0 
500         
 200 83 0.415 29.0 31 0.155 14.5 51 0.255 19.0 1 0.005 1.0
Positive Control: Mitomycin-C 
 0.0625    
 200 42 0.210 17.0 15 0.075 7.5 27 0.135 10.5 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 23 0.460 40.0 9 0.180 16.0 14 0.280 26.0 0 0.000 0.0
Trend: 7.544 5.690 5.357  
Probability: 0.000 0.000 0.000