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Study Information
Study Attribute Value
CEBS Accession Number: 002-01294-0001-0000-9
Chemical Name: 2-Biphenylamine hydrochloride
CASRN: 2185-92-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 404342_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
No Activation  2  Negative 
Induced Rat Liver S9  1_S9  Negative 
Induced Rat Liver S9  2_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 02/05/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1041 502 0.482 10.04 27.0 0.000
Test Chemical 2-Biphenylamine hydrochloride 
1.6       
 50 1033 539 0.522 10.78 27.0 8.202 
5         
 50 1046 522 0.499 10.44 27.0 3.487 
16         
 50 1046 525 0.502 10.50 27.0 4.082 
50         
 50 1043 573 0.549 11.46 27.0 13.925 
160         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1046 726 0.694 14.52 27.0 43.930
Mitomycin-C 
 0.005     
 10 206 254 1.233 25.40 27.0 155.690
Trend: 1.635        
Probability: 0.051        

Trial #: 2    Activation: No Activation    Date: 04/02/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 450 0.429 9.00 26.5 0.000
Test Chemical 2-Biphenylamine hydrochloride 
25         
 50 1051 443 0.422 8.86 26.5 -1.837 
25         
 50 1048 462 0.441 9.24 31.0 2.667 
50         
 50 1049 455 0.434 9.10 31.0 1.015 
75         
 19 398 203 0.510 10.68 31.0 18.785
Positive Control Mitomycin-C 
 0.001     
 50 1049 588 0.561 11.76 26.5 30.542
Mitomycin-C 
 0.005     
 10 210 251 1.195 25.10 26.5 178.358
Trend: 1.514        
Probability: 0.065        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 02/05/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 458 0.436 9.16 26.5 0.000
Test Chemical 2-Biphenylamine hydrochloride 
5         
 50 1048 429 0.409 8.58 26.5 -6.153 
16         
 50 1044 430 0.412 8.60 26.5 -5.574 
50         
 50 1045 418 0.400 8.36 26.5 -8.297 
160         
 50 1050 508 0.484 10.16 26.5 10.917 
500         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.3       
 50 1050 687 0.654 13.74 26.5 50.000
Cyclophosphamide 
2         
 10 211 402 1.905 40.20 26.5 336.785
Trend: 1.350        
Probability: 0.088        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 03/14/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 457 0.436 9.14 26.0 0.000
Test Chemical 2-Biphenylamine hydrochloride 
50         
 50 1049 398 0.379 7.96 26.0 -13.076 
100         
 50 1050 462 0.440 9.24 26.0 0.805 
200         
 50 1050 432 0.411 8.64 26.0 -5.741 
300         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.2       
 50 1049 749 0.714 14.98 26.0 63.582
Cyclophosphamide 
 0.6       
 10 209 242 1.158 24.20 26.0 165.277
Trend: -0.106        
Probability: 0.542