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Study Information
Study Attribute Value
CEBS Accession Number: 002-01294-0024-0000-4
Chemical Name: 2-Biphenylamine hydrochloride
CASRN: 2185-92-4
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 047126_CA
Study Result: Negative

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 12/13/84 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.3257
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
200         
 8 2.00 ± 1.00 0.0281
Test Chemical 2-Biphenylamine hydrochloride 
125         
 8 0.50 ± 0.50 0.5000
  
250         
 8 1.00 ± 0.38 0.2062
  
500         
 6 0.67 ± 0.67 0.3861
Vehicle Control No Stressor 
 0         
 8 0.50 ± 0.33 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 05/10/88 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.0148
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
50         
 8 20.50 ± 3.38 0.0000
Test Chemical 2-Biphenylamine hydrochloride 
62.5       
 8 0.75 ± 0.53 0.7116
  
125         
 8 1.75 ± 0.80 0.2451
  
250         
 8 2.75 ± 0.65 0.0584
Vehicle Control No Stressor 
 0         
 7 1.14 ± 0.59 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 08/29/88 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.1763
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Dimethylbenzanthracene 
50         
 8 19.00 ± 1.73 0.0000
Test Chemical 2-Biphenylamine hydrochloride 
187.5       
 8 1.00 ± 0.53 0.3521
  
250         
 8 1.50 ± 0.50 0.1573
Vehicle Control No Stressor 
 0         
 8 0.75 ± 0.75 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed