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Study Information
Study Attribute Value
CEBS Accession Number: 002-01309-0001-0000-6
Chemical Name: 2-Chloroacetophenone (CN)
CASRN: 532-27-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 037856_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 06/25/1987    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1037 438 0.422 8.76 26.0 0.000
Test Chemical 2-Chloroacetophenone (CN) 
 0.016     
 50 1042 411 0.394 8.22 26.0 -6.615 
 0.05      
 50 1043 439 0.421 8.78 26.0 -0.348 
 0.16      
 50 1042 397 0.381 7.94 26.0 -9.796 
 0.5       
 50 1050 428 0.408 8.56 26.0 -3.493
Positive Control Mitomycin-C 
 0.0E-4    
 50 1048 537 0.512 10.74 26.0 21.316
Mitomycin-C 
 0.005     
 10 210 273 1.300 27.30 26.0 207.785
Trend: -0.689        
Probability: 0.755        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 06/26/1987    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1048 454 0.433 9.08 26.0 0.000
Test Chemical 2-Chloroacetophenone (CN) 
 0.16      
 50 1046 386 0.369 7.72 26.0 -14.815 
 0.5       
 50 1050 466 0.444 9.32 26.0 2.448 
1.6       
 50 1052 453 0.431 9.06 26.0 -0.600 
5         
 50 1052 407 0.387 8.14 26.0 -10.693
Positive Control Cyclophosphamide 
 0.1       
 50 1050 592 0.564 11.84 26.0 30.148
Cyclophosphamide 
 0.6       
 10 210 244 1.162 24.40 26.0 168.211
Trend: -0.499        
Probability: 0.691