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Study Information
Study Attribute Value
CEBS Accession Number: 002-01309-0002-0000-7
Chemical Name: 2-Chloroacetophenone (CN)
CASRN: 532-27-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 037856_CA
Study Result: Weakly Positive

Study Result: Weakly Positive
Activation Trial Trial Call
No Activation  1  Questionable 
Induced Rat Liver S9  1_S9  Negative 
No Activation  2  Weakly Positive* 

Trial #:1   Activation: No Activation    Date: 11/12/1987    Harvest Time: 12 hour(s)   Trial Call: Questionable   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 2 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 2-Chloroacetophenone (CN) 
 0.16      
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 
 0.5       
 200 8 0.040 4.0 0 0.000 0.0 8 0.040 4.0 0 0.000 0.0 
1.6       
 200 7 0.035 3.0 2 0.010 1.0 5 0.025 2.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.0625    
 200 41 0.205 18.5 17 0.085 8.5 24 0.120 11.5 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 23 0.460 40.0 5 0.100 10.0 18 0.360 34.0 0 0.000 0.0
Trend: 1.913 -0.196 2.366  
Probability: 0.028 0.578 0.009  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 11/12/1987    Harvest Time: 13 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: 2-Chloroacetophenone (CN) 
1.6       
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0 
5         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0 
10         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
2.5       
 200 37 0.185 17.0 11 0.055 5.5 26 0.130 13.0 0 0.000 0.0
Cyclophosphamide 
7.5       
 50 21 0.420 36.0 7 0.140 14.0 14 0.280 22.0 0 0.000 0.0
Trend: -0.904 0.000 -0.904  
Probability: 0.817 0.000 0.817  


Trial #:2   Activation: No Activation    Date: 12/16/1987    Harvest Time: 12 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0
Test Chemical: 2-Chloroacetophenone (CN) 
 0.5       
 200 4 0.020 1.5 1 0.005 0.5 3 0.015 1.0 0 0.000 0.0 
1         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 
1.6       
 200 7 0.035 3.5 3 0.015 1.5 4 0.020 2.0 0 0.000 0.0 
3         
 65 38 0.585 43.1 2 0.031 3.1 34 0.523 38.5 2 0.031 2.0
Positive Control: Mitomycin-C 
 0.125     
 200 39 0.195 18.0 12 0.060 6.0 27 0.135 13.5 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 18 0.360 32.0 8 0.160 16.0 10 0.200 20.0 0 0.000 0.0
Trend: 8.542 2.421 8.019  
Probability: 0.000 0.008 0.000