COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-01311-0001-0000-9
Chemical Name: 2-Chloroethanol (ethylene chlorohydrin)
CASRN: 107-07-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 165108_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 03/21/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1027 438 0.426 8.76 26.0 0.000
Test Chemical 2-Chloroethanol (ethylene chlorohydrin) 
119.1       
 50 1024 488 0.477 9.76 26.0 11.742 
396.6       
 50 1033 519 0.502 10.38 26.0 17.805 
1200         
 50 1032 599 0.580 11.98 26.0 36.095 
4000         
 50 1028 1257 1.223 25.14 26.0 186.707 
11900         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.0015    
 50 1036 644 0.622 12.88 26.0 45.755
Mitomycin-C 
 0.01      
 5 105 207 1.971 41.40 26.0 362.250
Trend: 21.519        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 04/10/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1024 485 0.474 9.70 26.0 0.000
Test Chemical 2-Chloroethanol (ethylene chlorohydrin) 
4000         
 25 525 649 1.236 25.96 26.0 161.002 
5000         
 25 518 611 1.180 24.44 34.0 149.040 
6000         
 25 519 695 1.339 27.80 34.0 182.732 
11900         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.0015    
 50 1033 648 0.627 12.96 26.0 32.444
Mitomycin-C 
 0.01      
 5 107 165 1.542 33.00 26.0 225.580
Trend: 18.750        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 03/21/1984    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1038 455 0.438 9.10 26.0 0.000
Test Chemical 2-Chloroethanol (ethylene chlorohydrin) 
40         
 50 1036 524 0.506 10.48 26.0 15.387 
119.1       
 50 1039 548 0.527 10.96 26.0 20.324 
396.6       
 50 1036 706 0.681 14.12 26.0 55.464 
1200         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1041 686 0.659 13.72 26.0 50.335
Cyclophosphamide 
2         
 5 101 178 1.762 35.60 26.0 302.054
Trend: 7.418        
Probability: 0.000