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Study Information
Study Attribute Value
CEBS Accession Number: 002-01311-0002-0000-0
Chemical Name: 2-Chloroethanol (ethylene chlorohydrin)
CASRN: 107-07-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 165108_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Test Failure 
Induced Rat Liver S9  1_S9  Positive 
No Activation  2  Test Failure 

Trial #:1   Activation: No Activation    Date: 04/24/1984    Harvest Time: 20.5 hour(s)   Trial Call: Test Failure   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Medium 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 2-Chloroethanol (ethylene chlorohydrin) 
8900         
 100 5 0.050 4.0 1 0.010 1.0 4 0.040 3.0 0 0.000 0.0 
10100         
 100 5 0.050 5.0 1 0.010 1.0 4 0.040 4.0 0 0.000 0.0 
10900         
 100 22 0.220 16.0 4 0.040 4.0 18 0.180 13.0 0 0.000 0.0 
11900         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.025     
 100 4 0.040 4.0 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0
Mitomycin-C 
 0.062     
 25 8 0.320 28.0 5 0.200 20.0 3 0.120 12.0 0 0.000 0.0
Trend: 4.350 2.105 3.946  
Probability: 0.000 0.018 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 04/24/1984    Harvest Time: 20.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 3 0.030 1.0 0 0.000 0.0 3 0.030 1.0 0 0.000 0.0
Medium 
0         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: 2-Chloroethanol (ethylene chlorohydrin) 
794         
 100 8 0.080 5.0 4 0.040 4.0 4 0.040 2.0 0 0.000 0.0 
980         
 100 20 0.200 15.0 14 0.140 11.0 6 0.060 5.0 0 0.000 0.0 
2000         
 100 71 0.710 38.0 28 0.280 22.0 43 0.430 27.0 0 0.000 0.0 
2900         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
12.5       
 100 12 0.120 11.0 4 0.040 4.0 8 0.080 7.0 0 0.000 0.0
Cyclophosphamide 
25         
 25 8 0.320 24.0 3 0.120 12.0 5 0.200 20.0 0 0.000 0.0
Trend: 7.675 5.405 7.010  
Probability: 0.000 0.000 0.000  


Trial #:2   Activation: No Activation    Date: 05/24/1984    Harvest Time: 20.5 hour(s)   Trial Call: Test Failure   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Medium 
0         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: 2-Chloroethanol (ethylene chlorohydrin) 
9520         
 100 7 0.070 7.0 5 0.050 5.0 2 0.020 2.0 0 0.000 0.0 
10100         
 100 15 0.150 12.0 6 0.060 6.0 9 0.090 7.0 0 0.000 0.0 
10700         
 100 20 0.200 16.0 7 0.070 7.0 13 0.130 11.0 0 0.000 0.0 
11300         
 50 25 0.500 38.0 2 0.040 4.0 21 0.420 32.0 2 0.040 4.0 
11900         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.025     
 100 10 0.100 9.0 5 0.050 5.0 5 0.050 5.0 0 0.000 0.0
Mitomycin-C 
 0.062     
 25 10 0.400 36.0 4 0.160 16.0 6 0.240 20.0 0 0.000 0.0
Trend: 5.995 1.823 5.833  
Probability: 0.000 0.034 0.000