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Study Information
Study Attribute Value
CEBS Accession Number: 002-01311-0010-0000-9
Chemical Name: 2-Chloroethanol (ethylene chlorohydrin)
CASRN: 107-07-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: 951597
Study Result: Positive


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Negative and Non-Toxic
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 106 74 107 34 41
    88 113 115 44
    83 111 118 47
    92 103 104 38
Test Chemical 2-Chloroethanol (ethylene chlorohydrin) 
312.5       
 104 98 86 28 32
    95 88 101 36
  
625         
 64 86 56 29 30
    94 74 88 31
  
1250         
 69 79 54 26 32
    67 75 75 37
  
2500         
 77 68 81 35 36
    95 71 103 36
  
5000         
 66 58 88 45 35
    73 86 57 26
Positive Control Methyl Methane Sulfonate 
15         
 49 35 312 214 241*
    36 27 287 268

Nonactivation Trial: 2 Experiment Call: Negative and Non-Toxic
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 74 117 126 57 57
    78 66 139 60
    76 110 119 52
    78 108 141 61
Test Chemical 2-Chloroethanol (ethylene chlorohydrin) 
2000         
 87 103 153 59 56
    81 102 131 54
  
3000         
 71 97 146 69 65
    72 96 130 60
  
4000         
 91 90 178 65 66
    111 96 222 67
  
5000         
 59 83 124 70 71
    69 95 148 72
Positive Control Methyl Methane Sulfonate 
15         
 25 16 344 465 465*
    7r 3 166 772

Induced S9 Trial: 1 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 54 108 82 51 47
    74 120 77 35
    52 82 88 56
    55 90 73 45
Test Chemical 2-Chloroethanol (ethylene chlorohydrin) 
20         
 59 69 114 64 57
    59 107 87 49
  
40         
 67 85 128 64 59
    71 95 114 54
  
80         
 72 94 210 98 98*
    49 65 143 98
  
160         
 66 40 661 336 370*
    63 37 767 404
  
320         
 16 2 524 1103 1227*
    7r 1 297 1350
Positive Control 3-Methylcholanthrene 
2.5       
 52 31 709 453 458*
    49 34 685 463

Induced S9 Trial: 2 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Dimethyl Sulfoxide 
 0         
 60 94 71 39 43
    60 105 70 39
    56 102 87 52
    62 99 79 42
Test Chemical 2-Chloroethanol (ethylene chlorohydrin) 
40         
 60 88 65 36 36
    48 81 51 36
  
100         
 56 52 53 32 46
    53 37 95 60
  
160         
 48 22 166 116 125*
    52 27 209 134
  
220         
 26 9 221 289 291*
    19 6 168 292
  
280         
 8r 1 136 555
   
  
340         
   
Positive Control 3-Methylcholanthrene 
2.5       
 37 20 400 359 344*
    36 16 357 329

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination