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Study Information
Study Attribute Value
CEBS Accession Number: 002-01311-0011-0000-0
Chemical Name: 2-Chloroethanol (ethylene chlorohydrin)
CASRN: 107-07-3
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 208472_SCE
Study Result: Negative


Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.


Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 03/03/86 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Phosphate Buffered Saline 
 0         
 4 6.06 ± 0.280
Test Chemical 2-Chloroethanol (ethylene chlorohydrin) 
25         
 4 4.79 ± 0.228
  
50         
 4 5.92 ± 0.316
  
100         
 4 5.26 ± 0.567
Positive Control Mitomycin-C 
 0.5       
 4 11.81 ± 0.620


Summary of Sister Chromatid Exchange Data (Trial 2)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 08/18/87 42 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  42 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Phosphate Buffered Saline 
 0         
 3 5.17 ± 0.932
Test Chemical 2-Chloroethanol (ethylene chlorohydrin) 
25         
 4 4.50 ± 0.237
  
50         
 4 4.14 ± 0.349
  
100         
 4 6.21 ± 0.935
Positive Control Mitomycin-C 
 0.5       
 4 4.00 ± 0.145


Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed