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Study Information
Study Attribute Value
CEBS Accession Number: 002-01311-0012-0000-1
Chemical Name: 2-Chloroethanol (ethylene chlorohydrin)
CASRN: 107-07-3
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 208472_CA
Study Result: Negative

Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 03/24/86 17 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 17 hour 0.7157
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Mitomycin-C 
1         
 8 3.50 ± 0.91 0.0035
Test Chemical 2-Chloroethanol (ethylene chlorohydrin) 
25         
 8 1.75 ± 0.59 0.1015
  
50         
 8 0.50 ± 0.33 0.6731
  
100         
 8 0.75 ± 0.37 0.5000
Vehicle Control No Stressor 
 0         
 8 0.75 ± 0.37 0.0000


Test Type Start Date Sample Time (h) Species Sex Tissue Protocol Trend Test P
CA 10/27/87 36 Mouse Male Bone Marrow Intraperitoneal Injection x 1/study, 36 hour 0.1355
Test Group Dose
(mg/kg)		 n Percent Cells w/ Aberrations
(Mean ± SEM)		 Pairwise P
Positive Control Mitomycin-C 
1         
 8 10.25 ± 1.91 0.0000
Test Chemical 2-Chloroethanol (ethylene chlorohydrin) 
25         
 8 1.00 ± 0.53 0.7378
  
50         
 8 1.00 ± 0.38 0.7378
  
100         
 8 2.25 ± 0.70 0.2171
Vehicle Control No Stressor 
 0         
 8 1.50 ± 0.50 0.0000


Footnotes:
IP/IJ: Intraperitoneal Injection
INHAL: Inhalation
n: Number of animals analyzed