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Study Information
Study Attribute Value
CEBS Accession Number: 002-01311-0013-0000-2
Chemical Name: 2-Chloroethanol (ethylene chlorohydrin)
CASRN: 107-07-3
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 495716_SCE
Study Result: Negative


Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.


Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 02/13/86 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Phosphate Buffered Saline 
 0         
 4 5.43 ± 0.412
Test Chemical 2-Chloroethanol (ethylene chlorohydrin) 
18.75      
 4 3.67 ± 0.166
  
37.5       
 4 3.59 ± 0.306
  
75         
 4 5.23 ± 0.283
Positive Control Mitomycin-C 
 0.5       
 4 9.08 ± 0.669


Summary of Sister Chromatid Exchange Data (Trial 2)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 05/27/87 36 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  36 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Phosphate Buffered Saline 
 0         
 3 4.07 ± 0.498
Test Chemical 2-Chloroethanol (ethylene chlorohydrin) 
18.75      
 4 4.51 ± 0.358
  
37.5       
 4 4.23 ± 0.100
  
75         
 3 3.78 ± 0.294
Positive Control Mitomycin-C 
1         
 4 4.07 ± 0.335


Summary of Sister Chromatid Exchange Data (Trial 3)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 02/16/88 42 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  42 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Phosphate Buffered Saline 
 0         
 4 3.42 ± 0.539
Test Chemical 2-Chloroethanol (ethylene chlorohydrin) 
18.8       
 4 3.12 ± 0.216
  
37.5       
 4 4.29 ± 1.032
  
75         
 4 7.46 ± 2.137
Positive Control Mitomycin-C 
 0.5       
 4 8.54 ± 0.955


Summary of Sister Chromatid Exchange Data (Trial 4)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 01/03/90 42 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  42 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Phosphate Buffered Saline 
 0         
 4 3.37 ± 0.277
Test Chemical 2-Chloroethanol (ethylene chlorohydrin) 
18.75      
 4 3.35 ± 0.272
  
37.5       
 4 3.12 ± 0.095
  
75         
 4 3.19 ± 0.219
Positive Control Mitomycin-C 
 0.5       
 4 9.10 ± 1.013


Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed