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Study Information
Study Attribute Value
CEBS Accession Number: 002-01313-0001-0000-1
Chemical Name: 2-Chloroethyltrimethylammonium chloride
CASRN: 999-81-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 022395_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Weakly Positive 
No Activation  3  Positive 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 02/12/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1045 388 0.371 7.76 27.5 0.000
Test Chemical 2-Chloroethyltrimethylammonium chloride 
160         
 50 1041 381 0.366 7.62 27.5 -1.427 
500         
 50 1042 422 0.405 8.44 27.5 9.076 
1600         
 50 1040 494 0.475 9.88 27.5 27.932 
5000         
 50 1049 489 0.466 9.78 27.5 25.550
Positive Control Mitomycin-C 
 0.0E-4    
 50 1043 532 0.510 10.64 27.5 37.376
Mitomycin-C 
 0.001     
 50 1045 605 0.579 12.10 27.5 55.928
Trend: 4.732        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 04/30/1985    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1052 413 0.393 8.26 26.5 0.000
Test Chemical 2-Chloroethyltrimethylammonium chloride 
1600         
 50 1045 474 0.454 9.48 26.5 15.539 
3000         
 50 1047 486 0.464 9.72 26.5 18.238 
4000         
 50 1050 475 0.452 9.50 26.5 15.231 
5000         
 50 1052 530 0.504 10.60 26.5 28.329
Positive Control Mitomycin-C 
 0.001     
 50 1049 582 0.555 11.64 26.5 41.323
Mitomycin-C 
 0.005     
 10 210 221 1.052 22.10 26.5 168.064
Trend: 3.284        
Probability: 0.001        

Trial #: 3    Activation: No Activation    Date: 07/02/1985    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1048 398 0.380 7.96 26.0 0.000
Test Chemical 2-Chloroethyltrimethylammonium chloride 
1600         
 50 1046 539 0.515 10.78 26.0 35.686 
3000         
 50 1049 539 0.514 10.78 26.0 35.298 
4000         
 50 1049 563 0.537 11.26 26.0 41.322 
5000         
 50 1051 563 0.536 11.26 26.0 41.054
Positive Control Mitomycin-C 
 0.0E-4    
 50 1050 727 0.692 14.54 26.0 82.315
Mitomycin-C 
 0.005     
 10 210 272 1.295 27.20 26.0 241.058
Trend: 4.966        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 02/14/1985    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1049 416 0.397 8.32 26.0 0.000
Test Chemical 2-Chloroethyltrimethylammonium chloride 
160         
 50 1046 438 0.419 8.76 26.0 5.590 
500         
 50 1045 440 0.421 8.80 26.0 6.174 
1600         
 50 1048 406 0.387 8.12 26.0 -2.311 
5000         
 50 1046 411 0.393 8.22 26.0 -0.919
Positive Control Cyclophosphamide 
 0.3       
 50 1050 719 0.685 14.38 26.0 72.672
Trend: -0.625        
Probability: 0.734