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Study Information
Study Attribute Value
CEBS Accession Number: 002-01313-0002-0000-2
Chemical Name: 2-Chloroethyltrimethylammonium chloride
CASRN: 999-81-5
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 022395_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 04/10/1985    Harvest Time: 14.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 2-Chloroethyltrimethylammonium chloride 
1000         
 100 4 0.040 3.0 1 0.010 1.0 3 0.030 2.0 0 0.000 0.0 
1600         
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 
3000         
 100 3 0.030 2.0 1 0.010 1.0 2 0.020 1.0 0 0.000 0.0 
5000         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.125     
 100 25 0.250 19.0 18 0.180 15.0 7 0.070 6.0 0 0.000 0.0
Mitomycin-C 
 0.25      
 50 19 0.380 32.0 12 0.240 20.0 7 0.140 14.0 0 0.000 0.0
Trend: 0.706 -0.012 0.871  
Probability: 0.240 0.505 0.192  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 04/10/1985    Harvest Time: 14.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 3 0.030 3.0 0 0.000 0.0 3 0.030 3.0 0 0.000 0.0
Test Chemical: 2-Chloroethyltrimethylammonium chloride 
1000         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
1600         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0 
3000         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
5000         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
7.5       
 100 38 0.380 31.0 24 0.240 21.0 14 0.140 13.0 0 0.000 0.0
Cyclophosphamide 
15         
 50 34 0.680 52.0 21 0.420 32.0 13 0.260 22.0 0 0.000 0.0
Trend: -0.260 -0.077 -0.249  
Probability: 0.602 0.530 0.598