Study Attribute | Value |
---|---|
CEBS Accession Number: | 002-01313-0002-0000-2 |
Chemical Name: | 2-Chloroethyltrimethylammonium chloride |
CASRN: | 999-81-5 |
NTP Study Type: | Genetic Toxicology - Mammalian Cell Cytogenetics |
NTP Study ID: | 022395_CA |
Study Result: | Negative |
Activation | Trial | Trial Call |
---|---|---|
No Activation | 1 | Negative |
Induced Rat Liver S9 | 1_S9 | Negative |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 100 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
Test Chemical: | 2-Chloroethyltrimethylammonium chloride | 1000 | 100 | 4 | 0.040 | 3.0 | 1 | 0.010 | 1.0 | 3 | 0.030 | 2.0 | 0 | 0.000 | 0.0 |
1600 | 100 | 2 | 0.020 | 2.0 | 1 | 0.010 | 1.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | ||
3000 | 100 | 3 | 0.030 | 2.0 | 1 | 0.010 | 1.0 | 2 | 0.020 | 1.0 | 0 | 0.000 | 0.0 | ||
5000 | 100 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Mitomycin-C | 0.125 | 100 | 25 | 0.250 | 19.0 | 18 | 0.180 | 15.0 | 7 | 0.070 | 6.0 | 0 | 0.000 | 0.0 |
Mitomycin-C | 0.25 | 50 | 19 | 0.380 | 32.0 | 12 | 0.240 | 20.0 | 7 | 0.140 | 14.0 | 0 | 0.000 | 0.0 | |
Trend: | 0.706 | -0.012 | 0.871 | ||||||||||||
Probability: | 0.240 | 0.505 | 0.192 |
Dose µg/mL | Total Cells Examined | Total Aberrations | Complex Aberrations | Simple Aberrations | Other Abs | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. of Abs | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | No. of Abs. | Abs Per Cell | % Cells With Abs | ||||
Vehicle Control: | Negative (Not Specified) | 0 | 100 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 | 3 | 0.030 | 3.0 | 0 | 0.000 | 0.0 |
Test Chemical: | 2-Chloroethyltrimethylammonium chloride | 1000 | 100 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 |
1600 | 100 | 1 | 0.010 | 1.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 0 | 0.000 | 0.0 | ||
3000 | 100 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | 1 | 0.010 | 1.0 | 0 | 0.000 | 0.0 | ||
5000 | 100 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | 2 | 0.020 | 2.0 | 0 | 0.000 | 0.0 | ||
Positive Control: | Cyclophosphamide | 7.5 | 100 | 38 | 0.380 | 31.0 | 24 | 0.240 | 21.0 | 14 | 0.140 | 13.0 | 0 | 0.000 | 0.0 |
Cyclophosphamide | 15 | 50 | 34 | 0.680 | 52.0 | 21 | 0.420 | 32.0 | 13 | 0.260 | 22.0 | 0 | 0.000 | 0.0 | |
Trend: | -0.260 | -0.077 | -0.249 | ||||||||||||
Probability: | 0.602 | 0.530 | 0.598 |