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Study Information
Study Attribute Value
CEBS Accession Number: 002-01314-0001-0000-2
Chemical Name: 2-Chloromethylpyridine hydrochloride
CASRN: 6959-47-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 448657_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 11/16/1982    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1012 443 0.438 8.86 25.5 0.000
Test Chemical 2-Chloromethylpyridine hydrochloride 
3         
 50 1040 464 0.446 9.28 25.5 1.920 
9         
 50 1025 494 0.482 9.88 25.5 10.098 
30         
 50 1013 557 0.550 11.14 25.5 25.610 
90         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1024 610 0.596 12.20 25.5 36.084
Mitomycin-C 
 0.01      
 5 104 265 2.548 53.00 25.5 482.089
Trend: 3.852        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 12/07/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1035 412 0.398 8.24 25.8 0.000
Test Chemical 2-Chloromethylpyridine hydrochloride 
10         
 50 1031 672 0.652 13.44 25.8 63.740 
19.9       
 50 1030 1062 1.031 21.24 31.8 159.018 
30.2       
 0 0 0 0.000 0.00 31.8 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1024 579 0.565 11.58 25.8 42.044
Mitomycin-C 
 0.01      
 5 104 161 1.548 32.20 25.8 288.898
Trend: 17.362        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 11/16/1982    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1027 472 0.460 9.44 25.8 0.000
Test Chemical 2-Chloromethylpyridine hydrochloride 
9         
 50 1036 454 0.438 9.08 25.8 -4.649 
30         
 50 1019 458 0.449 9.16 25.8 -2.204 
90         
 50 1025 569 0.555 11.38 25.8 20.786 
300         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.3       
 50 1026 586 0.571 11.72 25.8 24.274
Cyclophosphamide 
2         
 5 102 96 0.941 19.20 25.8 104.786
Trend: 3.049        
Probability: 0.001        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 12/07/1982    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Water 
0         
 50 1031 431 0.418 8.62 25.4 0.000
Test Chemical 2-Chloromethylpyridine hydrochloride 
79.4       
 50 1017 703 0.691 14.06 25.4 65.354 
90.5       
 50 1030 765 0.743 15.30 31.4 77.667 
149.9       
 50 1034 917 0.887 18.34 31.4 112.144 
201         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.3       
 50 1046 563 0.538 11.26 25.4 28.753
Cyclophosphamide 
2         
 5 104 182 1.750 36.40 25.4 318.619
Trend: 12.453        
Probability: 0.000