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Study Information
Study Attribute Value
CEBS Accession Number: 002-01314-0002-0000-3
Chemical Name: 2-Chloromethylpyridine hydrochloride
CASRN: 6959-47-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 448657_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
Induced Rat Liver S9  1_S9  Positive 

Trial #:1   Activation: No Activation    Date: 01/06/1983    Harvest Time: 20 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0
Water 
0         
 100 2 0.020 2.0 2 0.020 2.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 2-Chloromethylpyridine hydrochloride 
30.2       
 100 8 0.080 7.0 2 0.020 2.0 6 0.060 6.0 0 0.000 0.0 
39.6       
 100 24 0.240 17.0 4 0.040 4.0 20 0.200 15.0 0 0.000 0.0 
50.3       
 100 43 0.430 27.0 9 0.090 8.0 34 0.340 23.0 0 0.000 0.0 
74.8       
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.0625    
 50 13 0.260 22.0 8 0.160 16.0 4 0.080 8.0 1 0.020 2.0
Trend: 5.560 2.226 5.550  
Probability: 0.000 0.013 0.000  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 01/06/1983    Harvest Time: 20.7 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Water 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 2-Chloromethylpyridine hydrochloride 
175.5       
 50 114 2.280 32.0 13 0.260 12.0 1 0.020 1.0 100 2.000 20.0 
200         
 50 191 3.820 48.0 4 0.080 8.0 6 0.120 10.0 181 3.620 38.0 
225         
 50 223 4.460 56.0 14 0.280 12.0 8 0.160 10.0 201 4.020 42.0 
250         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
10         
 50 9 0.180 12.0 3 0.060 6.0 6 0.120 8.0 0 0.000 0.0
Trend: 8.084 2.806 3.512  
Probability: 0.000 0.003 0.000