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Study Information
Study Attribute Value
CEBS Accession Number: 002-01314-0013-0000-5
Chemical Name: 2-Chloromethylpyridine hydrochloride
CASRN: 6959-47-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID: 861777
Study Result: Positive


Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Water 
 0         
 123r 93 237 64 63
    121r 269 170 47
    108 110 177 55
    119 90 256 72
Test Chemical 2-Chloromethylpyridine hydrochloride 
6.25      
 120 82 209 58 61
    116 81 209 60
    119 92 227 64
  
12.5       
 118 72 317 89 88
    121r 68 298 82
    111 73 289 87
  
25         
 118 63 459 130 150*
    102 55 469 153
    110 56 553 168
  
50         
 296*
    64 7 666 350
    83 6 601 242
  
75         
   
   
Positive Control Methyl Methane Sulfonate 
5         
 84 43 933 370 380*
    74 39 912 409
    81 33 869 360

Nonactivation Trial: 2 Experiment Call: Positive
  Conc.
ug/mL 		Cloning
Efficiency 		Relative Total
Growth 		Mutant Colonies Mutant Frequency Avg Mutant Frequency
Vehicle Control Water 
 0         
 105 115 137 44 36
    97 92 109 37
    102 109 83 27
    91# 84 98 36
Test Chemical 2-Chloromethylpyridine hydrochloride 
10         
 100 103 111 37 36
    109 109 124 38
    100 115 97 32
  
20         
 155r 108 177 38 41
    98# 93 119 41
    107 101 136 42
  
30         
 121r 91 217 60 63*
    108 87 214 66
    108 78 194 60
  
40         
 84 43 342 137 136*
    81 43 348 143
    97 49 367 127
  
50         
 71 17 427 202 232*
    55 10 470 287
    64 18 396 208
  
60         
   
   
Positive Control Methyl Methane Sulfonate 
5         
 61 43 488 267 257*
    54# 52 466.5 288
    81 78 528 216

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination