Genetic Toxicology - Mammalian Cell Mutagenicity

Study Information
Study Attribute	Value
CEBS Accession Number:	002-01314-0013-0000-5
Chemical Name:	2-Chloromethylpyridine hydrochloride
CASRN:	6959-47-3
NTP Study Type:	Genetic Toxicology - Mammalian Cell Mutagenicity
NTP Study ID:	861777
Study Result:	Positive

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Table Instructions and Notes:
Studies are indicated to be "Nontoxic" when the observed reductions in relative total growth did not indicate that the maximum tolerated dose was achieved.

Nonactivation Trial: 1 Experiment Call: Positive
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Water	0	123r	93	237	64	63
			121r	269	170	47
			108	110	177	55
			119	90	256	72
Test Chemical	2-Chloromethylpyridine hydrochloride	6.25	120	82	209	58	61
			116	81	209	60
			119	92	227	64
		12.5	118	72	317	89	88
			121r	68	298	82
			111	73	289	87
		25	118	63	459	130	150*
			102	55	469	153
			110	56	553	168
		50					296*
			64	7	666	350
			83	6	601	242
		75


Positive Control	Methyl Methane Sulfonate	5	84	43	933	370	380*
			74	39	912	409
			81	33	869	360

Nonactivation Trial: 2 Experiment Call: Positive
		Conc. ug/mL	Cloning Efficiency	Relative Total Growth	Mutant Colonies	Mutant Frequency	Avg Mutant Frequency
Vehicle Control	Water	0	105	115	137	44	36
			97	92	109	37
			102	109	83	27
			91#	84	98	36
Test Chemical	2-Chloromethylpyridine hydrochloride	10	100	103	111	37	36
			109	109	124	38
			100	115	97	32
		20	155r	108	177	38	41
			98#	93	119	41
			107	101	136	42
		30	121r	91	217	60	63*
			108	87	214	66
			108	78	194	60
		40	84	43	342	137	136*
			81	43	348	143
			97	49	367	127
		50	71	17	427	202	232*
			55	10	470	287
			64	18	396	208
		60


Positive Control	Methyl Methane Sulfonate	5	61	43	488	267	257*
			54#	52	466.5	288
			81	78	528	216

Footnotes:
Asterisks(*) indicate significant responses.
r = rejected value due to quality control criteria
# = reduced sample size because of the loss of one culture dish due to contamination