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Study Information
Study Attribute Value
CEBS Accession Number: 002-01314-0014-0000-6
Chemical Name: 2-Chloromethylpyridine hydrochloride
CASRN: 6959-47-3
NTP Study Type: Genetic Toxicology - Rodent Cytogenetics
NTP Study ID: 145263_SCE
Study Result: Negative (Nonstandard Protocol)


Table Instructions and Notes:

Below is a summary of Sister Chromatid Exchange data. Use the link below the summary tables to view detailed data for that specific trial.


Summary of Sister Chromatid Exchange Data (Trial 1)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 06/19/85 23 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  23 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Phosphate Buffered Saline 
 0         
 4 6.40 ± 0.515
Test Chemical 2-Chloromethylpyridine hydrochloride 
75         
 4 5.12 ± 0.509
  
150         
 4 3.60 ± 0.445
  
300         
 4 8.39 ± 0.698
Positive Control Mitomycin-C 
6.9       
 4 43.12 ± 3.091


Summary of Sister Chromatid Exchange Data (Trial 2)
Test Type Start Date Sample Time (h) Species Sex Strain Tissue Protocol Trend
Test P
SCE 07/10/85 17 Mouse Male B6C3F1 Bone Marrow IP/IJ x 1,  17 hour
  Dose
(mg/kg)		 n SCE / Cell
(Mean ± SEM)		 Pairwise P
Vehicle Control Phosphate Buffered Saline 
 0         
 4 3.61 ± 0.189
Test Chemical 2-Chloromethylpyridine hydrochloride 
75         
 4 4.42 ± 0.479
  
150         
 4 4.46 ± 0.341
  
300         
 4 4.62 ± 0.391
Positive Control Mitomycin-C 
1         
 4 11.24 ± 0.150


Footnotes:
IP/IJ: Intraperitoneal Injection
n: Number of animals analyzed