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Study Information
Study Attribute Value
CEBS Accession Number: 002-01316-0001-0000-4
Chemical Name: 2-Chloronitrobenzene
CASRN: 88-73-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 680124_SCE
Study Result: Weakly Positive

Study Result: Weakly Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Weakly Positive 
Induced Rat Liver S9  2_S9  Weakly Positive 

Trial #: 1    Activation: No Activation    Date: 07/22/1990    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 386 0.368 7.72 26.0 0.000
Negative (Not Specified) 
0         
 50 1047 429 0.410 8.58 26.0 11.352
Test Chemical 2-Chloronitrobenzene 
5         
 50 1052 450 0.428 9.00 26.0 16.248 
17         
 50 1049 443 0.422 8.86 26.0 14.767 
50         
 50 1047 453 0.433 9.06 26.0 17.582 
167         
 0 0 0 0.000 0.00 31.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1050 618 0.589 12.36 26.0 59.951
Mitomycin-C 
 0.004     
 10 210 265 1.262 26.50 26.0 242.937
Trend: 2.131        
Probability: 0.017        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 07/22/1990    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1052 412 0.392 8.24 26.0 0.000
Negative (Not Specified) 
0         
 50 1050 394 0.375 7.88 26.0 -4.187
Test Chemical 2-Chloronitrobenzene 
50         
 50 1050 418 0.398 8.36 26.0 1.650 
167         
 50 1051 439 0.418 8.78 26.0 6.655 
500         
 50 1041 568 0.546 11.36 26.0 39.321 
1667         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.125     
 50 1047 647 0.618 12.94 26.0 57.789
Cyclophosphamide 
 0.5       
 10 209 221 1.057 22.10 26.0 170.000
Trend: 5.197        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 11/08/1990    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 409 0.390 8.18 26.0 0.000
Negative (Not Specified) 
0         
 50 1044 403 0.386 8.06 26.0 -0.901
Test Chemical 2-Chloronitrobenzene 
63         
 50 1048 453 0.432 9.06 26.0 10.969 
125         
 50 1049 432 0.412 8.64 26.0 5.724 
250         
 50 1051 503 0.479 10.06 26.0 22.866 
500         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.125     
 50 1052 502 0.477 10.04 26.0 22.505
Cyclophosphamide 
 0.5       
 10 210 216 1.029 21.60 26.0 164.059
Trend: 2.738        
Probability: 0.003