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Study Information
Study Attribute Value
CEBS Accession Number: 002-01316-0003-0000-6
Chemical Name: 2-Chloronitrobenzene
CASRN: 88-73-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 743462_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Weakly Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 12/15/1982    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1043 426 0.408 8.52 26.0 0.000
Test Chemical 2-Chloronitrobenzene 
5         
 50 1045 440 0.421 8.80 26.0 3.089 
16         
 50 1044 450 0.431 9.00 26.0 5.533 
50         
 50 1047 528 0.504 10.56 26.0 23.470
Positive Control Mitomycin-C 
 0.005     
 25 523 732 1.400 29.28 26.0 242.676
Trend: 3.234        
Probability: 0.001        

Trial #: 2    Activation: No Activation    Date: 02/24/1983    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 428 0.408 8.56 26.0 0.000
Test Chemical 2-Chloronitrobenzene 
30         
 50 1047 454 0.434 9.08 26.0 6.277 
40         
 50 1047 427 0.408 8.54 26.0 -0.043 
50         
 50 1048 547 0.522 10.94 26.0 27.926 
60         
 50 1044 473 0.453 9.46 26.0 11.043 
75         
 15 310 163 0.526 10.87 26.0 28.872
Positive Control Mitomycin-C 
 0.005     
 25 525 619 1.179 24.76 26.0 188.977
Trend: 3.385        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 12/15/1982    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 451 0.430 9.02 26.0 0.000
Test Chemical 2-Chloronitrobenzene 
50         
 50 1051 480 0.457 9.60 26.0 6.329 
160         
 50 1047 500 0.478 10.00 26.0 11.182 
500         
 50 1049 511 0.487 10.22 26.0 13.412
Positive Control Cyclophosphamide 
1         
 50 1048 1117 1.066 22.34 26.0 148.144
Trend: 2.063        
Probability: 0.020