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Study Information
Study Attribute Value
CEBS Accession Number: 002-01316-0004-0000-7
Chemical Name: 2-Chloronitrobenzene
CASRN: 88-73-3
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 743462_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Questionable 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 12/15/1982    Harvest Time: 14 hour(s)   Trial Call: Questionable   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 2 0.020 2.0 0 0.000 0.0 2 0.020 2.0 0 0.000 0.0
Test Chemical: 2-Chloronitrobenzene 
16         
 100 8 0.080 7.0 1 0.010 1.0 7 0.070 6.0 0 0.000 0.0 
50         
 100 8 0.080 8.0 0 0.000 0.0 8 0.080 8.0 0 0.000 0.0 
160         
 100 11 0.110 9.0 3 0.030 3.0 8 0.080 8.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.15      
 50 21 0.420 34.0 7 0.140 14.0 14 0.280 24.0 0 0.000 0.0
Trend: 1.995 1.804 1.881  
Probability: 0.023 0.036 0.030  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 12/15/1982    Harvest Time: 14 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Dimethyl Sulfoxide 
0         
 100 4 0.040 4.0 1 0.010 1.0 3 0.030 3.0 0 0.000 0.0
Test Chemical: 2-Chloronitrobenzene 
50         
 100 8 0.080 8.0 2 0.020 2.0 6 0.060 6.0 0 0.000 0.0 
160         
 100 6 0.060 6.0 4 0.040 4.0 2 0.020 2.0 0 0.000 0.0 
500         
 100 6 0.060 6.0 4 0.040 4.0 2 0.020 2.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
15         
 50 14 0.280 26.0 3 0.060 6.0 11 0.220 20.0 0 0.000 0.0
Trend: 0.376 1.506 -0.885  
Probability: 0.353 0.066 0.812