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Study Information
Study Attribute Value
CEBS Accession Number: 002-01325-0001-0000-4
Chemical Name: 2-Ethylhexanol
CASRN: 104-76-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 463951_SCE
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #: 1    Activation: No Activation    Date: 03/07/1989    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1041 369 0.354 7.38 26.0 -6.244
Dimethyl Sulfoxide 
0         
 50 1058 400 0.378 8.00 26.0 0.000
Test Chemical 2-Ethylhexanol 
1.7       
 50 1056 418 0.396 8.36 26.0 4.698 
5         
 50 1063 430 0.405 8.60 26.0 6.994 
17         
 50 1055 458 0.434 9.16 26.0 14.826 
50         
 50 1056 424 0.402 8.48 26.0 6.201 
167         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1045 627 0.600 12.54 26.0 58.700
Mitomycin-C 
 0.005     
 10 210 268 1.276 26.80 26.0 237.552
Trend: 1.396        
Probability: 0.081        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 03/07/1989    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Negative (Not Specified) 
0         
 50 1052 396 0.376 7.92 26.0 -1.999
Dimethyl Sulfoxide 
0         
 50 1057 406 0.384 8.12 26.0 0.000
Test Chemical 2-Ethylhexanol 
5         
 50 1053 402 0.382 8.04 26.0 -0.609 
17         
 50 1052 421 0.400 8.42 26.0 4.187 
50         
 50 1063 383 0.360 7.66 26.0 -6.197 
167         
 50 1054 400 0.380 8.00 31.0 -1.197 
500         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.125     
 50 1053 555 0.527 11.10 26.0 37.219
Cyclophosphamide 
 0.5       
 10 211 176 0.834 17.60 26.0 117.160
Trend: -0.489        
Probability: 0.688