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Study Information
Study Attribute Value
CEBS Accession Number: 002-01325-0002-0000-5
Chemical Name: 2-Ethylhexanol
CASRN: 104-76-7
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 463951_CA
Study Result: Negative

Study Result: Negative
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Negative 

Trial #:1   Activation: No Activation    Date: 03/30/1989    Harvest Time: 15.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: 2-Ethylhexanol 
50         
 200 3 0.015 1.0 1 0.005 0.5 2 0.010 1.0 0 0.000 0.0 
108         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0 
233         
 200 2 0.010 1.0 0 0.000 0.0 2 0.010 1.0 0 0.000 0.0 
500         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.1       
 200 40 0.200 16.0 21 0.105 9.0 19 0.095 9.5 0 0.000 0.0
Mitomycin-C 
 0.4       
 50 18 0.360 26.0 11 0.220 18.0 7 0.140 14.0 0 0.000 0.0
Trend: 0.366 -0.001 0.200  
Probability: 0.357 0.500 0.421  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 03/30/1989    Harvest Time: 12.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Test Chemical: 2-Ethylhexanol 
50         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
108         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
233         
 200 5 0.025 1.5 1 0.005 0.5 4 0.020 1.5 0 0.000 0.0 
500         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
5         
 200 32 0.160 11.5 12 0.060 5.0 20 0.100 7.5 0 0.000 0.0
Cyclophosphamide 
15         
 50 11 0.220 20.0 6 0.120 10.0 5 0.100 10.0 0 0.000 0.0
Trend: 1.346 1.343 1.346  
Probability: 0.089 0.090 0.089