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Study Information
Study Attribute Value
CEBS Accession Number: 002-01330-0001-0000-0
Chemical Name: 2-Ethylhexyl glycidyl ether
CASRN: 2461-15-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 879421_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Positive 
Induced Rat Liver S9  1_S9  Weakly Positive 

Trial #: 1    Activation: No Activation    Date: 08/01/1989    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1049 424 0.404 8.48 26.0 0.000
Negative (Not Specified) 
0         
 50 1048 402 0.384 8.04 26.0 -5.098
Test Chemical 2-Ethylhexyl glycidyl ether 
1.7       
 50 1043 503 0.482 10.06 26.0 19.315 
5         
 50 1045 562 0.538 11.24 26.0 33.055 
17         
 50 1052 671 0.638 13.42 26.0 57.803 
50         
 0 0 0 0.000 0.00 0.0 N/A 
167         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1048 579 0.552 11.58 26.0 36.687
Mitomycin-C 
 0.004     
 10 210 223 1.062 22.30 26.0 162.721
Trend: 7.652        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 08/22/1989    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 421 0.401 8.42 26.0 0.000
Negative (Not Specified) 
0         
 50 1045 418 0.400 8.36 26.0 -0.238
Test Chemical 2-Ethylhexyl glycidyl ether 
4.7       
 50 1047 497 0.475 9.94 26.0 18.391 
9.4       
 50 1046 544 0.520 10.88 26.0 29.710 
19         
 50 1043 721 0.691 14.42 26.0 72.408 
38         
 0 0 0 0.000 0.00 0.0 N/A 
75         
 0 0 0 0.000 0.00 0.0 N/A 
150         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.001     
 50 1045 534 0.511 10.68 26.0 27.448
Mitomycin-C 
 0.004     
 10 210 195 0.929 19.50 26.0 131.591
Trend: 9.184        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 08/01/1989    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1046 402 0.384 8.04 26.0 0.000
Negative (Not Specified) 
0         
 50 1050 413 0.393 8.26 26.0 2.345
Test Chemical 2-Ethylhexyl glycidyl ether 
5         
 50 1045 424 0.406 8.48 26.0 5.574 
17         
 50 1047 475 0.454 9.50 26.0 18.046 
50         
 50 1050 550 0.524 11.00 26.0 36.295 
167         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.125     
 50 1043 579 0.555 11.58 26.0 44.444
Cyclophosphamide 
 0.5       
 10 209 205 0.981 20.50 26.0 155.219
Trend: 5.058        
Probability: 0.000