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Study Information
Study Attribute Value
CEBS Accession Number: 002-01342-0001-0000-3
Chemical Name: 2-Mercaptobenzothiazole
CASRN: 149-30-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 748636_SCE
Study Result: Not a Valid Test

Study Result: Not a Valid Test
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Weakly Positive 
Induced Rat Liver S9  2_S9  Test Failure 

Trial #: 1    Activation: No Activation    Date: 04/24/1984    Trial Call: Negative   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1035 500 0.483 10.00 25.3 0.000
Test Chemical 2-Mercaptobenzothiazole 
12.5       
 50 1036 471 0.455 9.42 32.6 -5.891 
14.9       
 50 1027 515 0.501 10.30 32.6 3.802 
20.1       
 50 1025 568 0.554 11.36 32.6 14.708 
24.8       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.0015    
 50 1027 741 0.722 14.82 25.3 49.354
Mitomycin-C 
 0.01      
 5 104 205 1.971 41.00 25.3 308.029
Trend: 2.698        
Probability: 0.003        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 04/24/1984    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1038 477 0.460 9.54 25.3 0.000
Test Chemical 2-Mercaptobenzothiazole 
99.2       
 50 1028 531 0.517 10.62 25.3 12.404 
247.5       
 50 1026 536 0.522 10.72 25.3 13.683 
501.5       
 50 1045 640 0.612 12.80 32.6 33.273 
750         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1020 634 0.622 12.68 25.3 35.260
Cyclophosphamide 
2         
 5 104 142 1.365 28.40 25.3 197.121
Trend: 4.541        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 05/17/1984    Trial Call: Test Failure   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1025 454 0.443 9.08 25.6 0.000
Test Chemical 2-Mercaptobenzothiazole 
351.6       
 50 1032 558 0.541 11.16 36.6 22.074 
401.6       
 50 1035 624 0.603 12.48 36.6 36.117 
445.3       
 50 1041 588 0.565 11.76 36.6 27.525 
502.3       
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1035 702 0.678 14.04 25.6 53.132
Cyclophosphamide 
2         
 5 108 183 1.694 36.60 25.6 282.556
Trend: 4.284        
Probability: 0.000