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Study Information
Study Attribute Value
CEBS Accession Number: 002-01342-0002-0000-4
Chemical Name: 2-Mercaptobenzothiazole
CASRN: 149-30-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 748636_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #:1   Activation: No Activation    Date: 05/24/1984    Harvest Time: 20.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 5 0.050 2.0 0 0.000 0.0 5 0.050 2.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Test Chemical: 2-Mercaptobenzothiazole 
10         
 100 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 0 0.000 0.0 
14.9       
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0 
19.9       
 100 2 0.020 2.0 1 0.010 1.0 1 0.010 1.0 0 0.000 0.0 
30.1       
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Mitomycin-C 
 0.025     
 100 12 0.120 10.0 7 0.070 7.0 5 0.050 4.0 0 0.000 0.0
Mitomycin-C 
 0.0625    
 25 14 0.560 10.0 8 0.320 28.0 6 0.240 20.0 0 0.000 0.0
Trend: 1.328 0.583 1.291  
Probability: 0.092 0.280 0.098  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 06/19/1984    Harvest Time: 20.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 50 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 50 1 0.020 2.0 0 0.000 0.0 1 0.020 2.0 0 0.000 0.0
Test Chemical: 2-Mercaptobenzothiazole 
373.5       
 25 12 0.480 24.0 7 0.280 12.0 5 0.200 20.0 0 0.000 0.0 
399         
 25 17 0.680 28.0 6 0.240 12.0 11 0.440 28.0 0 0.000 0.0 
425         
 25 21 0.840 28.0 8 0.320 24.0 13 0.520 24.0 0 0.000 0.0 
450         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
3.8       
 50 3 0.060 6.0 2 0.040 4.0 1 0.020 2.0 0 0.000 0.0
Cyclophosphamide 
12.5       
 25 9 0.360 20.0 5 0.200 16.0 4 0.160 16.0 0 0.000 0.0
Trend: 3.231 3.271 3.028  
Probability: 0.001 0.001 0.001  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 05/24/1984    Harvest Time: 20.5 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Negative (Not Specified) 
0         
 100 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Dimethyl Sulfoxide 
0         
 100 1 0.010 1.0 0 0.000 0.0 1 0.010 1.0 0 0.000 0.0
Test Chemical: 2-Mercaptobenzothiazole 
351.8       
 100 18 0.180 9.0 11 0.110 8.0 7 0.070 5.0 0 0.000 0.0 
400.8       
 100 14 0.140 9.0 9 0.090 7.0 5 0.050 5.0 0 0.000 0.0 
451         
 50 24 0.480 16.0 21 0.420 14.0 3 0.060 6.0 0 0.000 0.0 
500.5       
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
2.5       
 100 4 0.040 4.0 0 0.000 0.0 3 0.030 3.0 1 0.010 1.0
Cyclophosphamide 
12.5       
 25 12 0.480 36.0 4 0.160 12.0 8 0.320 32.0 0 0.000 0.0
Trend: 3.137 3.108 1.573  
Probability: 0.001 0.001 0.058