COVID-19 is an emerging, rapidly evolving situation.

Get the latest public health information from CDC and research information from NIH.

U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Share This:
Study Information
Study Attribute Value
CEBS Accession Number: 002-01342-0003-0000-5
Chemical Name: 2-Mercaptobenzothiazole
CASRN: 149-30-4
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 997320_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Questionable 
Induced Rat Liver S9  1_S9  Weakly Positive 

Trial #: 1    Activation: No Activation    Date: 06/21/1988    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1050 391 0.372 7.82 26.0 0.000
Test Chemical 2-Mercaptobenzothiazole 
 0.5       
 50 1046 439 0.420 8.78 26.0 12.706 
1.6       
 50 1042 475 0.456 9.50 26.0 22.416 
5         
 50 1046 486 0.465 9.72 26.0 24.772 
16         
 50 1045 449 0.430 8.98 26.0 15.383
Positive Control Mitomycin-C 
 0.0E-4    
 50 1049 524 0.500 10.48 26.0 34.143
Mitomycin-C 
 0.005     
 10 210 320 1.524 32.00 26.0 309.207
Trend: 2.498        
Probability: 0.006        

Trial #: 2    Activation: No Activation    Date: 07/19/1988    Trial Call: Questionable   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 368 0.351 7.36 26.0 0.000
Test Chemical 2-Mercaptobenzothiazole 
 0.5       
 50 1050 458 0.436 9.16 26.0 24.101 
1.6       
 50 1050 398 0.379 7.96 26.0 7.843 
5         
 50 1048 365 0.348 7.30 26.0 -0.910 
16         
 50 1045 319 0.305 6.38 26.0 -13.149
Positive Control Mitomycin-C 
 0.0E-4    
 50 1049 517 0.493 10.34 26.0 40.221
Mitomycin-C 
 0.005     
 10 210 245 1.167 24.50 26.0 231.929
Trend: -3.057        
Probability: 0.999        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 06/21/1988    Trial Call: Weakly Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Dimethyl Sulfoxide 
0         
 50 1047 377 0.360 7.54 26.0 0.000
Test Chemical 2-Mercaptobenzothiazole 
5         
 50 1030 434 0.421 8.68 26.0 17.019 
16         
 50 1033 400 0.387 8.00 26.0 7.539 
50         
 50 1042 466 0.447 9.32 26.0 24.201 
160         
 50 1033 443 0.429 8.86 26.0 19.099
Positive Control Cyclophosphamide 
 0.1       
 50 1048 543 0.518 10.86 26.0 43.894
Cyclophosphamide 
 0.6       
 10 210 218 1.038 21.80 26.0 188.299
Trend: 2.612        
Probability: 0.005