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Study Information
Study Attribute Value
CEBS Accession Number: 002-01344-0001-0000-5
Chemical Name: 2-Methoxyethyl acetate
CASRN: 110-49-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 216435_SCE
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Positive 
No Activation  2  Questionable 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Positive 

Trial #: 1    Activation: No Activation    Date: 07/08/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1043 317 0.304 6.34 26.0 0.000
Test Chemical 2-Methoxyethyl acetate 
151         
 50 1048 348 0.332 6.96 26.5 9.255 
503         
 50 1035 395 0.382 7.90 26.5 25.569 
1510         
 50 1041 528 0.507 10.56 26.5 66.882 
5030         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.002     
 50 1041 479 0.460 9.58 26.0 51.394
Mitomycin-C 
 0.01      
 20 420 290 0.690 14.50 26.0 127.182
Trend: 7.669        
Probability: 0.000        

Trial #: 2    Activation: No Activation    Date: 08/20/1986    Trial Call: Questionable   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1048 474 0.452 9.48 26.5 0.000
Test Chemical 2-Methoxyethyl acetate 
765         
 50 1044 440 0.421 8.80 26.5 -6.817 
1020         
 50 1047 489 0.467 9.78 26.5 3.263 
1280         
 50 1039 531 0.511 10.62 26.5 12.996 
1530         
 50 1047 565 0.540 11.30 26.5 19.312 
2040         
 0 0 0 0.000 0.00 0.0 N/A
Positive Control Mitomycin-C 
 0.0015    
 25 521 989 1.898 39.56 26.5 319.702
Mitomycin-C 
 0.01      
 10 210 828 3.943 82.80 26.5 771.754
Trend: 3.852        
Probability: 0.000        

Trial #: 1_S9    Activation: Induced Rat Liver S9    Date: 09/03/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1041 478 0.459 9.56 25.5 0.000
Test Chemical 2-Methoxyethyl acetate 
1000         
 50 1045 511 0.489 10.22 25.5 6.495 
1500         
 50 1038 574 0.553 11.48 25.5 20.431 
3000         
 50 1042 704 0.676 14.08 25.5 47.139 
5000         
 0 0 0 0.000 0.00 29.5 N/A
Positive Control Cyclophosphamide 
 0.5       
 50 1044 627 0.601 12.54 25.5 30.795
Cyclophosphamide 
2.5       
 10 210 271 1.290 27.10 25.5 181.043
Trend: 7.096        
Probability: 0.000        

Trial #: 2_S9    Activation: Induced Rat Liver S9    Date: 09/18/1986    Trial Call: Positive   
  Dose
µg/mL		 Number
Cells
Examined		 Number
Chromosomes
Examined		 Total
Number
SCEs		 SCE /
Chromosome		 SCE /
Cell		 Hours in
BRDU		 % Increase
Over Solvent
Control
Vehicle Control Medium 
0         
 50 1032 474 0.459 9.48 26.0 0.000
Test Chemical 2-Methoxyethyl acetate 
1500         
 50 1011 504 0.499 10.08 26.0 8.538 
2000         
 50 1030 596 0.579 11.92 26.0 25.983 
2990         
 50 1024 769 0.751 15.38 26.0 63.504 
3990         
 0 0 0 0.000 0.00 26.0 N/A
Positive Control Cyclophosphamide 
 0.4       
 50 1042 646 0.620 12.92 26.0 34.979
Cyclophosphamide 
2.5       
 10 207 271 1.309 27.10 26.0 185.036
Trend: 9.185        
Probability: 0.000