U.S. flag

An official website of the United States government

Dot gov

The .gov means it's official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you're on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Study Information
Study Attribute Value
CEBS Accession Number: 002-01344-0002-0000-6
Chemical Name: 2-Methoxyethyl acetate
CASRN: 110-49-6
NTP Study Type: Genetic Toxicology - Mammalian Cell Cytogenetics
NTP Study ID: 216435_CA
Study Result: Positive

Study Result: Positive
Activation Trial Trial Call
No Activation  1  Negative 
Induced Rat Liver S9  1_S9  Positive 
Induced Rat Liver S9  2_S9  Weakly Positive* 

Trial #:1   Activation: No Activation    Date: 07/17/1986    Harvest Time: 10.5 hour(s)   Trial Call: Negative   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Medium 
0         
 200 3 0.015 1.5 1 0.005 0.5 2 0.010 1.0 0 0.000 0.0
Test Chemical: 2-Methoxyethyl acetate 
501         
 200 4 0.020 0.5 2 0.010 0.5 2 0.010 0.5 0 0.000 0.0 
1500         
 200 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 0 0.000 0.0 
5010         
 200 1 0.005 0.5 0 0.000 0.0 1 0.005 0.5 0 0.000 0.0
Positive Control: Mitomycin-C 
1         
 200 54 0.270 21.0 28 0.140 12.5 26 0.130 11.0 0 0.000 0.0
Mitomycin-C 
5         
 50 67 1.340 48.0 22 0.440 34.0 14 0.280 20.0 31 0.620 4.0
Trend: -1.096 -0.786 -0.879  
Probability: 0.863 0.784 0.810  


Trial #:1_S9   Activation: Induced Rat Liver S9    Date: 09/09/1986    Harvest Time: 20 hour(s)   Trial Call: Positive   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Medium 
0         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0
Test Chemical: 2-Methoxyethyl acetate 
998         
 200 7 0.035 3.5 3 0.015 1.5 4 0.020 2.0 0 0.000 0.0 
1500         
 200 16 0.080 5.5 4 0.020 2.0 12 0.060 4.0 0 0.000 0.0 
2990         
 25 175 7.000 80.0 3 0.120 8.0 2 0.080 8.0 170 6.800 17.0 
4990         
 0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0
Positive Control: Cyclophosphamide 
50         
 10 58 5.800 100.0 18 1.800 70.0 10 1.000 50.0 30 3.000 3.0
Trend: 9.384 2.365 2.900  
Probability: 0.000 0.009 0.002  


Trial #:2_S9   Activation: Induced Rat Liver S9    Date: 07/17/1986    Harvest Time: 12.5 hour(s)   Trial Call: Weakly Positive*   
  Dose
µg/mL		 Total
Cells Examined		 Total Aberrations Complex Aberrations Simple Aberrations Other Abs
No. of
Abs		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs		 No. of
Abs.		 Abs
Per
Cell		 % Cells
With
Abs
Vehicle Control: Medium 
0         
 200 10 0.050 3.0 3 0.015 1.5 7 0.035 2.0 0 0.000 0.0
Test Chemical: 2-Methoxyethyl acetate 
501         
 200 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 0 0.000 0.0 
1500         
 200 2 0.010 1.0 1 0.005 0.5 1 0.005 0.5 0 0.000 0.0 
5010         
 50 104 2.080 54.0 16 0.320 30.0 8 0.160 16.0 80 1.600 8.0
Positive Control: Cyclophosphamide 
50         
 50 32 0.640 28.0 9 0.180 14.0 13 0.260 20.0 10 0.200 1.0
Trend: 8.365 6.299 3.337  
Probability: 0.000 0.000 0.000